ENSMUSG00000033419


Mus musculus

Features
Gene ID: ENSMUSG00000033419
  
Biological name :Snap91
  
Synonyms : Snap91 / synaptosomal-associated protein 91
  
Possible biological names infered from orthology : O60641 / synaptosome associated protein 91
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.1
Gene start: 86765923
Gene end: 86880654
  
Corresponding Affymetrix probe sets: 10595496 (MoGene1.0st)   1416688_at (Mouse Genome 430 2.0 Array)   1437817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141065
Ensembl peptide - ENSMUSP00000046189
Ensembl peptide - ENSMUSP00000074066
Ensembl peptide - ENSMUSP00000074095
Ensembl peptide - ENSMUSP00000096096
NCBI entrez gene - 20616     See in Manteia.
MGI - MGI:109132
RefSeq - XM_017313237
RefSeq - XM_006510895
RefSeq - XM_006510896
RefSeq - XM_006510897
RefSeq - XM_006510898
RefSeq - XM_006510899
RefSeq - XM_006510900
RefSeq - XM_006510901
RefSeq - XM_006510902
RefSeq - XM_006510903
RefSeq - XM_006510904
RefSeq - XM_017313236
RefSeq - NM_001277982
RefSeq - NM_001277983
RefSeq - NM_001277985
RefSeq - NM_001277986
RefSeq - NM_001357770
RefSeq - NM_013669
RefSeq - XM_006510894
RefSeq Peptide - NP_001264912
RefSeq Peptide - NP_001264914
RefSeq Peptide - NP_001264915
RefSeq Peptide - NP_001344699
RefSeq Peptide - NP_038697
RefSeq Peptide - NP_001264911
swissprot - E9QLK9
swissprot - E9Q9A3
swissprot - E9QQ05
swissprot - Q3TWS4
swissprot - A0A087WSI9
Ensembl - ENSMUSG00000033419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-214j24.9ENSDARG00000015931Danio rerio
 snap91ENSDARG00000098809Danio rerio
 SNAP91ENSGALG00000015846Gallus gallus
 O60641ENSG00000065609Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Picalm / Q7M6Y3 / Phosphatidylinositol-binding clathrin assembly protein / Q13492*ENSMUSG0000003936140


Protein motifs (from Interpro)
Interpro ID Name
 IPR008942  ENTH/VHS
 IPR011417  AP180 N-terminal homology (ANTH) domain
 IPR013809  ENTH domain
 IPR014712  Phosphoinositide-binding clathrin adaptor, domain 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005545 1-phosphatidylinositol binding IEA
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0020357 abnormal excitatory synapse morphology "any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0020358 abnormal inhibitory synapse morphology "any structural anomaly in a synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell" [GO:0060077]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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