ENSGALG00000039037


Gallus gallus

Features
Gene ID: ENSGALG00000039037
  
Biological name :PICALM
  
Synonyms : phosphatidylinositol binding clathrin assembly protein / PICALM
  
Possible biological names infered from orthology : Q13492 / Q7M6Y3
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 190435635
Gene end: 190483701
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000051655
swissprot - A0A1D5PFT8
Ensembl - ENSGALG00000039037
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 picalmaENSDARG00000012866Danio rerio
 picalmbENSDARG00000014137Danio rerio
 PICALMENSG00000073921Homo sapiens
 PicalmENSMUSG00000039361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000000840480
SNAP91 / clathrin coat assembly protein AP180 / O60641* / synaptosome associated protein 91* / synaptosomal-associated protein 91*ENSGALG0000001584675


Protein motifs (from Interpro)
Interpro ID Name
 IPR008942  ENTH/VHS
 IPR011417  AP180 N-terminal homology (ANTH) domain
 IPR013809  ENTH domain
 IPR014712  Phosphoinositide-binding clathrin adaptor, domain 2
 IPR030412  Phosphatidylinositol-binding clathrin assembly protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016050 vesicle organization IEA
 biological_processGO:0016188 synaptic vesicle maturation IEA
 biological_processGO:0016197 endosomal transport IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0035459 cargo loading into vesicle IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis IEA
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:0090647 modulation of age-related behavioral decline IEA
 biological_processGO:0097494 regulation of vesicle size IEA
 biological_processGO:0097753 membrane bending IEA
 biological_processGO:0098711 iron ion import across plasma membrane IEA
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 biological_processGO:2000009 negative regulation of protein localization to cell surface IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070381 endosome to plasma membrane transport vesicle IEA
 cellular_componentGO:0097418 neurofibrillary tangle IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005545 1-phosphatidylinositol binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0032050 clathrin heavy chain binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr