ENSMUSG00000003411


Mus musculus

Features
Gene ID: ENSMUSG00000003411
  
Biological name :Rab3b
  
Synonyms : Q9CZT8 / Rab3b / RAB3B, member RAS oncogene family
  
Possible biological names infered from orthology : P20337
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 108879063
Gene end: 108943324
  
Corresponding Affymetrix probe sets: 10506883 (MoGene1.0st)   1422583_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102262
Ensembl peptide - ENSMUSP00000003502
Ensembl peptide - ENSMUSP00000102261
NCBI entrez gene - 69908     See in Manteia.
MGI - MGI:1917158
RefSeq - NM_023537
RefSeq Peptide - NP_076026
swissprot - A2A7Z6
swissprot - Q0PD62
swissprot - Q9CZT8
Ensembl - ENSMUSG00000003411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab3bENSDARG00000114797Danio rerio
 RAB3BENSGALG00000010567Gallus gallus
 RAB3BENSG00000169213Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170080
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184079
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906677
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303746
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694344
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067144
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346042
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793542
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220239
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451138
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106237
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414736
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300333


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0018125 peptidyl-cysteine methylation IDA
 biological_processGO:0019882 antigen processing and presentation ISO
 biological_processGO:0051586 positive regulation of dopamine uptake involved in synaptic transmission ISO
 biological_processGO:0097494 regulation of vesicle size ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding ISO
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0031489 myosin V binding ISO


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr