ENSMUSG00000019066


Mus musculus

Features
Gene ID: ENSMUSG00000019066
  
Biological name :Rab3d
  
Synonyms : P35276 / Rab3d / RAB3D, member RAS oncogene family
  
Possible biological names infered from orthology : O95716
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21907491
Gene end: 21918192
  
Corresponding Affymetrix probe sets: 10591643 (MoGene1.0st)   1418890_a_at (Mouse Genome 430 2.0 Array)   1418891_a_at (Mouse Genome 430 2.0 Array)   1449259_at (Mouse Genome 430 2.0 Array)   1449260_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120067
Ensembl peptide - ENSMUSP00000111008
Ensembl peptide - ENSMUSP00000113322
Ensembl peptide - ENSMUSP00000114106
NCBI entrez gene - 19340     See in Manteia.
MGI - MGI:97844
RefSeq - XM_011242423
RefSeq - NM_001324531
RefSeq - NM_031874
RefSeq - XM_011242422
RefSeq Peptide - NP_001311460
RefSeq Peptide - NP_114080
swissprot - P35276
swissprot - D3YWL1
swissprot - Q543Q4
swissprot - D3YW33
Ensembl - ENSMUSG00000019066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab3daENSDARG00000018107Danio rerio
 rab3dbENSDARG00000101534Danio rerio
 RAB3DENSG00000105514Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341177
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184076
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170075
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303746
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067144
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694344
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793542
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346041
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220240
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451140
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106238
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414737
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300332


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0018125 peptidyl-cysteine methylation IDA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:1903307 positive regulation of regulated secretory pathway IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0042588 zymogen granule IDA
 cellular_componentGO:0099503 secretory vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0031489 myosin V binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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