ENSMUSG00000024511


Mus musculus

Features
Gene ID: ENSMUSG00000024511
  
Biological name :Rab27b
  
Synonyms : Q99P58 / Rab27b / RAB27B, member RAS oncogene family
  
Possible biological names infered from orthology : O00194
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 69979131
Gene end: 70141605
  
Corresponding Affymetrix probe sets: 10459620 (MoGene1.0st)   1417214_at (Mouse Genome 430 2.0 Array)   1417215_at (Mouse Genome 430 2.0 Array)   1439610_at (Mouse Genome 430 2.0 Array)   1443764_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068349
Ensembl peptide - ENSMUSP00000112807
Ensembl peptide - ENSMUSP00000114094
NCBI entrez gene - 80718     See in Manteia.
MGI - MGI:1931295
RefSeq - XM_006526364
RefSeq - NM_001082553
RefSeq - NM_001302798
RefSeq - NM_001302799
RefSeq - NM_030554
RefSeq Peptide - NP_001289727
RefSeq Peptide - NP_001289728
RefSeq Peptide - NP_085031
RefSeq Peptide - NP_001076022
swissprot - Q549X4
swissprot - Q99P58
Ensembl - ENSMUSG00000024511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab27bENSDARG00000087762Danio rerio
 O00194ENSG00000041353Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220272
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906640
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341139
Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*ENSMUSG0000003184039
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303739
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694339
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170039
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067137
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793536
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106234
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414734
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300334
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0032402 melanosome transport IBA
 biological_processGO:0045921 positive regulation of exocytosis IBA
 biological_processGO:0071985 multivesicular body sorting pathway ISO
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005795 Golgi stack ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISO
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0032585 multivesicular body membrane ISO
 cellular_componentGO:0042470 melanosome IBA
 cellular_componentGO:0042589 zymogen granule membrane IEA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019003 GDP binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0031489 myosin V binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0004725 decreased platelet serotonin level "reduced concentration of serotonin in the platelets; this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0008327 abnormal corticotroph morphology "any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0010899 abnormal pulmonary alveolar system morphology 
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

 MP:0020432 decreased platelet dense granule number "decreased number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1.2Seab/Rab27btm1.2Seab
Genetic Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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