ENSG00000041353


Homo sapiens

Features
Gene ID: ENSG00000041353
  
Biological name :RAB27B
  
Synonyms : O00194 / RAB27B / RAB27B, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q21.2
Gene start: 54717860
Gene end: 54895516
  
Corresponding Affymetrix probe sets: 207017_at (Human Genome U133 Plus 2.0 Array)   207018_s_at (Human Genome U133 Plus 2.0 Array)   228708_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262094
Ensembl peptide - ENSP00000465009
Ensembl peptide - ENSP00000468542
NCBI entrez gene - 5874     See in Manteia.
OMIM - 603869
RefSeq - XM_017025914
RefSeq - XM_005266733
RefSeq - XM_006722518
RefSeq - XM_011526131
RefSeq - XM_017025913
RefSeq - NM_004163
RefSeq Peptide - NP_004154
swissprot - K7ES41
swissprot - K7EJ38
swissprot - O00194
Ensembl - ENSG00000041353
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab27bENSDARG00000087762Danio rerio
 Q99P58ENSMUSG00000024511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51159 / RAB27A / RAB27A, member RAS oncogene familyENSG0000006997472
RAB3D / O95716 / RAB3D, member RAS oncogene familyENSG0000010551441
RAB3A / P20336 / RAB3A, member RAS oncogene familyENSG0000010564939
RAB3C / Q96E17 / RAB3C, member RAS oncogene familyENSG0000015293239
RAB8A / P61006 / RAB8A, member RAS oncogene familyENSG0000016746138
RAB8B / Q92930 / RAB8B, member RAS oncogene familyENSG0000016612838
RAB3B / P20337 / RAB3B, member RAS oncogene familyENSG0000016921338
RAB10 / P61026 / RAB10, member RAS oncogene familyENSG0000008473337
RAB13 / P51153 / RAB13, member RAS oncogene familyENSG0000014354536
RAB44 / RAB44, member RAS oncogene familyENSG0000025558735
RASEF / Q8IZ41 / RAS and EF-hand domain containingENSG0000016510535
RAB12 / Q6IQ22 / RAB12, member RAS oncogene familyENSG0000020641833
RAB15 / P59190 / RAB15, member RAS oncogene familyENSG0000013999833


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0032402 melanosome transport IBA
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0071985 multivesicular body sorting pathway IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005795 Golgi stack IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IDA
 cellular_componentGO:0030141 secretory granule IBA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031088 platelet dense granule membrane TAS
 cellular_componentGO:0032585 multivesicular body membrane IDA
 cellular_componentGO:0042470 melanosome IDA
 cellular_componentGO:0042589 zymogen granule membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031489 myosin V binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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