ENSDARG00000009511


Danio rerio

Features
Gene ID: ENSDARG00000009511
  
Biological name :tnfa
  
Synonyms : tnfa / tumor necrosis factor a (TNF superfamily, member 2)
  
Possible biological names infered from orthology : LTA / lymphotoxin A / lymphotoxin alpha / P01374 / P01375 / P06804 / P09225 / TNF / tumor necrosis factor
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 27019432
Gene end: 27024019
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000025726
NCBI entrez gene - 405785     See in Manteia.
RefSeq - NM_212859
RefSeq Peptide - NP_998024
swissprot - Q1L8A5
ZFIN ID - ZDB-GENE-050317-1
Ensembl - ENSDARG00000009511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LTAENSG00000226979Homo sapiens
 TNFENSG00000232810Homo sapiens
 LtaENSMUSG00000024402Mus musculus
 TnfENSMUSG00000024401Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*ENSDARG0000001359838
faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*ENSDARG0000009891316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002959  Tumour necrosis factor alpha
 IPR002960  Lymphotoxin-alpha
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002237 response to molecule of bacterial origin IDA
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0006954 inflammatory response IGI
 biological_processGO:0006955 immune response IDA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031099 regeneration IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0043330 response to exogenous dsRNA IDA
 biological_processGO:0046685 response to arsenic-containing substance IDA
 biological_processGO:0060729 intestinal epithelial structure maintenance IGI
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer cell proliferation delayed , abnormal
retinal inner nuclear layer cell proliferation decreased process quality , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism life span , ameliorated
whole organism increased amount , abnormal
Show

 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte decreased distribution , abnormal
hepatocyte decreased amount , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell regeneration process quality , abnormal
Show

 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell decreased height , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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