Manteia - Molecule gene

ENSMUSG00000024402

Mus musculus

Features

Gene ID:	ENSMUSG00000024402

Biological name :	Lta

Synonyms :	Lta / lymphotoxin A / P09225

Possible biological names infered from orthology :	lymphotoxin alpha / P01374

Species:	Mus musculus

Chr. number:	17
Strand:	-1
Band:	B1
Gene start:	35203165
Gene end:	35205351

Corresponding Affymetrix probe sets:	10450508 (MoGene1.0st) 1420353_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000025266 NCBI entrez gene - 16992 See in Manteia. MGI - MGI:104797 RefSeq - XM_006523731 RefSeq - NM_010735 RefSeq Peptide - NP_034865 swissprot - P09225 swissprot - Q542S2 Ensembl - ENSMUSG00000024402

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tnfa	ENSDARG00000009511	Danio rerio
tnfb	ENSDARG00000013598	Danio rerio
LTA	ENSG00000226979	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tnf / P06804 / tumor necrosis factor / P01375*	ENSMUSG00000024401	34
Tnfsf15 / tumor necrosis factor (ligand) superfamily, member 15 / O95150* / TNF superfamily member 15*	ENSMUSG00000050395	30
Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...	ENSMUSG00000000817	25
Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...	ENSMUSG00000005824	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR002960	Lymphotoxin-alpha
IPR006052	Tumour necrosis factor domain
IPR006053	Tumour necrosis factor
IPR008983	Tumour necrosis factor-like domain superfamily
IPR021184	Tumour necrosis factor, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001666	response to hypoxia	IEA
biological_process	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	IGI
biological_process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IGI
biological_process	GO:0006954	inflammatory response	TAS
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0006959	humoral immune response	IMP
biological_process	GO:0007584	response to nutrient	IEA
biological_process	GO:0008283	cell proliferation	TAS
biological_process	GO:0008284	positive regulation of cell proliferation	TAS
biological_process	GO:0009987	cellular process	TAS
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0032729	positive regulation of interferon-gamma production	IGI
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0044130	negative regulation of growth of symbiont in host	IGI
biological_process	GO:0048147	negative regulation of fibroblast proliferation	IEA
biological_process	GO:0048535	lymph node development	IMP
biological_process	GO:0050830	defense response to Gram-positive bacterium	IGI
biological_process	GO:0060252	positive regulation of glial cell proliferation	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0005164	tumor necrosis factor receptor binding	TAS
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

TNFR2 non-canonical NF-kB pathway

TNFs bind their physiological receptors

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000217	abnormal white blood cell count	"anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1⁺ Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fbn1^tm3Rmz/Fbn1⁺,Fbn2^tm1Rmz/Fbn2^tm1Rmz Genetic Background: involves: 129
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^tm1Dch/Lta^tm1Dch,Tg(Igk-Lta/Ltb)4Cys/0 Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned
MP:0001257	increased body length	"increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk,Mertk^nmf12/Mertk^nmf12 Genetic Background: involves: C57BL/6J
MP:0001501	abnormal sleep pattern	"deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv * C57BL/6
MP:0001798	impaired macrophage phagocytosis	"reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv * C57BL/6
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0001807	decreased IgA	"less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gnb5^flr/Gnb5^flr,Myo5a^flr/Myo5a^flr Genetic Background: involves: C57BL/6J * C57BL/10J * CBA/Ca
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002345	abnormal lymph node primary follicle	"anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6-Lta/Tnf^tm1Jods
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	"anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002362	abnormal spleen marginal zone morphology	"anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0002375	abnormal thymus medulla morphology	"anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ltbr^tm1Mmat/Ltbr^tm1Mmat Genetic Background: involves: C57BL/6 * CBA
MP:0002377	abnormal mucosa-associated lymphoid tissue morphology	"anomalous structure or development of the regional immune system associated with the mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6)
MP:0002378	abnormal gut-associated lymphoid tissue morphology	"anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cdk4^tm1Bbd/Cdk4^tm1Bbd,Cdk6^tm1Bbd/Cdk6^tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv Allelic Composition: Lta/Tnf^tm1Fda/Lta⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0002450	abnormal lymph organ development	"anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dlx5^tm1Jlr/Dlx5^tm1Jlr Genetic Background: B6.129X1-Dlx5^tm1Jlr Allelic Composition: Lta^tm1Dch/Lta^tm1Dch,Tg(Igk-Lta/Ltb)4Cys/0 Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0002460	decreased circulating immunoglobulin concentration	"less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0002619	abnormal lymphocyte morphology/development	"anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ltbr^tm1Mmat/Ltbr^tm1Mmat Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Lta^tm1Dch/Lta^tm1Dch,Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc Genetic Background: involves: 129S2/SvPas * 129X1/SvJ
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J
MP:0002723	abnormal immune serum protein physiology	"abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6)
MP:0002831	absent Peyer s patches	"lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6)
MP:0003436	resistance to induced arthritis	"less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0004357	long tibia	"increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6-Lta/Tnf^tm1Jods Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv * C57BL/6
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129 * C57BL/6J
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0005026	decreased susceptibility to parasitic infection	"reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fn1^tm2Bwg/Fn1^tm2Bwg Genetic Background: involves: 129S4/SvJae Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv * C57BL/6
MP:0005027	increased susceptibility to parasitic infection	"greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0005165	increased susceptibility to injury	"greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv * C57BL/6
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mc1r^e/Mc1r^e,Mlph^ln/Mlph^ln Genetic Background: Not Specified
MP:0005658	susceptibility to diet-induced obesity	"more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0006087	increased body mass index	"greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tas1r2^tm1Keiw/Tas1r2^tm1Keiw Genetic Background: involves: 129 * C57BL/6J
MP:0008024	absent lymph nodes	"absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta/Tnf^tm1Jods/Lta/Tnf^tm1Jods Genetic Background: C57BL/6J-Lta/Tnf^tm1Jods Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0008045	decreased NK cell number	"reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J
MP:0008169	increased B-1b cell number	"greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]	Show Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J
MP:0008183	absent marginal zone B cells	"absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J
MP:0008234	absent spleen marginal zone	"absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0008343	abnormal gamma-delta T cell morphology	"any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Rela^tm1Rsch/Rela^tm1Rsch,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0008450	retinal photoreceptor degeneration	"a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk,Mertk^nmf12/Mertk^nmf12 Genetic Background: involves: C57BL/6J
MP:0008464	absent peripheral lymph nodes	"absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Jods/Lta^tm1Jods Genetic Background: C57BL/6-Lta^tm1Jods
MP:0008465	absent mesenteric lymph nodes	"absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0008474	absent spleen germinal center	"absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^hlb382/Lta^hlb382 Genetic Background: C57BL/6J-Lta^hlb382/J Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhcgr^tm1Zmlei/Lhcgr^tm1Zmlei Genetic Background: either: 129X1/SvJ-Lhcgr^tm1Zmlei or (involves: 129X1/SvJ * C57BL/6) Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: involves: C57BL/6 Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0008496	decreased IgG2a level	"less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0008511	thin retinal inner nuclear layer	"reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk,Mertk^nmf12/Mertk^nmf12 Genetic Background: involves: C57BL/6J
MP:0008515	thin retinal outer nuclear layer	"reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk,Mertk^nmf12/Mertk^nmf12 Genetic Background: involves: C57BL/6J
MP:0008552	abnormal circulating tumor necrosis factor level	"anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned
MP:0008561	decreased tumor necrosis factor secretion	"reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta^tm1Tab/Lta^tm1Tab Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta/Tnf^tm1Fda/Lta/Tnf^tm1Fda Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lta/Tnf^tm1Fda/Lta⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0008578	decreased circulating interferon-gamma level	"reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0008734	decreased susceptibility to endotoxin shock	"less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta/Tnf^tm1Fda/Lta/Tnf^tm1Fda Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lta/Tnf^tm1Fda/Lta⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009544	abnormal thymus epithelium morphology	"any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]	Show Allelic Composition: Il13^tm1.1Anjm/Il13^tm1.1Anjm,Tg(DO11.10)10Dlo/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6 Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas Allelic Composition: Lta^tm1Dch/Lta^tm1Dch,Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc Genetic Background: involves: 129S2/SvPas * 129X1/SvJ
MP:0009622	absent inguinal lymph nodes	"absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0009628	absent brachial lymph nodes	"absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0009630	absent axillary lymph nodes	"absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0009633	absent cervical lymph nodes	"absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0009634	absent popliteal lymph nodes	"absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Ltb/Tnf/Lta^tm1Dvk/Ltb/Tnf/Lta^tm1Dvk Genetic Background: B6.Cg-Ltb/Tnf/Lta^tm1Dvk
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv * C57BL/6
MP:0009764	decreased sensitivity to induced morbidity/mortality	"increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: involves: 129/Sv
MP:0009788	increased susceptibility to bacterial infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lta^tm1.1Sned/Lta^tm1.1Sned Genetic Background: B6.129-Lta^tm1.1Sned Allelic Composition: Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug Genetic Background: B6.129-Lta/Tnf^tm1Eug
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Lta^{tm1.1(KOMP)Vlcg}/Lta^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Lta^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013588	small thymus medulla	"decreased size of the inner area of thymus lobules" [MGI:Anna]	Show Allelic Composition: Lta^tm1Dch/Lta^tm1Dch Genetic Background: involves: 129S2/SvPas Allelic Composition: Lta^tm1Dch/Lta^tm1Dch,Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024399	Ltb / P41155 / Lymphotoxin-beta / Q06643*	/ complex
ENSMUSG00000020941	Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*	/ reaction / complex
ENSMUSG00000024402	Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*	/ complex
ENSMUSG00000030339	Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*	/ reaction / complex
ENSMUSG00000026942	Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*	/ complex / reaction
ENSMUSG00000021277	Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*	/ complex / reaction
ENSMUSG00000057367	Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*	/ reaction / complex
ENSMUSG00000030341	P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*	/ complex / reaction
ENSMUSG00000028599	P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*	/ complex / reaction

1 s.

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