ENSMUSG00000050395


Mus musculus

Features
Gene ID: ENSMUSG00000050395
  
Biological name :Tnfsf15
  
Synonyms : Tnfsf15 / tumor necrosis factor (ligand) superfamily, member 15
  
Possible biological names infered from orthology : O95150 / TNF superfamily member 15
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C1
Gene start: 63727084
Gene end: 63745113
  
Corresponding Affymetrix probe sets: 10513722 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000050144
NCBI entrez gene - 326623     See in Manteia.
MGI - MGI:2180140
RefSeq - NM_177371
RefSeq Peptide - NP_796345
swissprot - F6VXB8
Ensembl - ENSMUSG00000050395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFSF15ENSGALG00000007174Gallus gallus
 O95150ENSG00000181634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*ENSMUSG0000002440223
Tnf / P06804 / tumor necrosis factor / P01375*ENSMUSG0000002440123
Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...ENSMUSG0000000081723
Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...ENSMUSG0000000582422


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008064  Tumor necrosis factor ligand superfamily member 15
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042107 cytokine metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

 MP:0010187 decreased T follicular helper cell number "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
Show

Allelic Composition: Shank3tm1.1Pfw/Shank3tm1.1Pfw
Genetic Background: B6.129S6-Shank3tm1.1Pfw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024793 Tnfrsf25 / tumor necrosis factor receptor superfamily, member 25 / Q93038* / TNF receptor superfamily member 25*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr