ENSMUSG00000005824


Mus musculus

Features
Gene ID: ENSMUSG00000005824
  
Biological name :Tnfsf14
  
Synonyms : Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, soluble form
  
Possible biological names infered from orthology : O43557 / TNF superfamily member 14
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 57189492
Gene end: 57194189
  
Corresponding Affymetrix probe sets: 10452307 (MoGene1.0st)   1421588_at (Mouse Genome 430 2.0 Array)   1450298_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005976
NCBI entrez gene - 50930     See in Manteia.
MGI - MGI:1355317
RefSeq - NM_019418
RefSeq Peptide - NP_062291
swissprot - A0A0U5JAA8
swissprot - Q9QYH9
Ensembl - ENSMUSG00000005824
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O43557ENSG00000125735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnfsf15 / tumor necrosis factor (ligand) superfamily, member 15 / O95150* / TNF superfamily member 15*ENSMUSG0000005039525
Fasl / P41047 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble ...ENSMUSG0000000081725
Tnf / P06804 / tumor necrosis factor / P01375*ENSMUSG0000002440123
Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*ENSMUSG0000002440221


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IDA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: EdnrbWS4/EdnrbWS4
Genetic Background: involves: BALB/c * MSM

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: EdnrbWS4/EdnrbWS4
Genetic Background: involves: BALB/c * MSM

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005327 abnormal mesangial cell "anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57971]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0008343 abnormal gamma-delta T cell morphology "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Relatm1Rsch/Relatm1Rsch,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009544 abnormal thymus epithelium morphology "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009634 absent popliteal lymph nodes "absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Ltatm1Dch/Ltatm1Dch,Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / reaction / complex
 ENSMUSG00000005824 Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...  / complex
 ENSMUSG00000030339 Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex






 

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