ENSMUSG00000024399


Mus musculus

Features
Gene ID: ENSMUSG00000024399
  
Biological name :Ltb
  
Synonyms : Ltb / Lymphotoxin-beta / P41155
  
Possible biological names infered from orthology : Q06643
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35194439
Gene end: 35196320
  
Corresponding Affymetrix probe sets: 10444752 (MoGene1.0st)   1419135_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134706
Ensembl peptide - ENSMUSP00000025262
NCBI entrez gene - 16994     See in Manteia.
MGI - MGI:104796
RefSeq - NM_008518
RefSeq Peptide - NP_032544
swissprot - P41155
swissprot - A0A0U5JAA2
swissprot - G3V002
Ensembl - ENSMUSG00000024399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LTBENSG00000227507Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002961  Lymphotoxin-beta
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IMP
 biological_processGO:0048535 lymph node development IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: ApcMin/Apc+,Recql4tm1Glu/Recql4tm1Glu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008179 absent germinal center B cells "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt,Tg(Lck-cre)1Jtak/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

 MP:0008464 absent peripheral lymph nodes "absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008473 abnormal spleen follicular dendritic cell network "any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0009634 absent popliteal lymph nodes "absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Krn/Ltbtm1Krn
Genetic Background: C57BL/6-Ltbtm1Krn

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbtm1Flv/Ltbtm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / reaction / complex
 ENSMUSG00000030339 Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000024402 Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*  / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000024399 Ltb / P41155 / Lymphotoxin-beta / Q06643*  / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex






 

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