ENSG00000135587


Homo sapiens

Features
Gene ID: ENSG00000135587
  
Biological name :SMPD2
  
Synonyms : O60906 / SMPD2 / sphingomyelin phosphodiesterase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q21
Gene start: 109440763
Gene end: 109443919
  
Corresponding Affymetrix probe sets: 205622_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258052
Ensembl peptide - ENSP00000399731
NCBI entrez gene - 6610     See in Manteia.
OMIM - 603498
RefSeq - XM_011536079
RefSeq - NM_003080
RefSeq - XM_005267109
RefSeq Peptide - NP_003071
swissprot - O60906
swissprot - H0Y5N2
Ensembl - ENSG00000135587
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpd2aENSDARG00000040523Danio rerio
 smpd2bENSDARG00000052701Danio rerio
 SMPD2ENSGALG00000033245Gallus gallus
 Smpd2ENSMUSG00000019822Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006684 sphingomyelin metabolic process TAS
 biological_processGO:0006687 glycosphingolipid metabolic process TAS
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046513 ceramide biosynthetic process IEA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Ceramide signalling
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000035681 NSMAF / Q92636 / neutral sphingomyelinase activation associated factor  / complex / reaction
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction
 ENSG00000204628 RACK1 / P63244 / receptor for activated C kinase 1  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / reaction / complex






 

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