ENSDARG00000040523


Danio rerio

Features
Gene ID: ENSDARG00000040523
  
Biological name :smpd2a
  
Synonyms : smpd2a / sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase)
  
Possible biological names infered from orthology : O60906 / O70572 / SMPD2 / sphingomyelin phosphodiesterase 2 / sphingomyelin phosphodiesterase 2, neutral
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 5565261
Gene end: 5587934
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000059306
Ensembl peptide - ENSDARP00000134756
NCBI entrez gene - 567548     See in Manteia.
swissprot - F1QUD7
ZFIN ID - ZDB-GENE-051014-1
Ensembl - ENSDARG00000040523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMPD2ENSGALG00000033245Gallus gallus
 SMPD2ENSG00000135587Homo sapiens
 Smpd2ENSMUSG00000019822Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smpd2b / sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase) / SMPD2* / O70572* / O60906* / sphingomyelin phosphodiesterase 2* / sphingomyelin phosphodiesterase ...ENSDARG0000005270153


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0006684 sphingomyelin metabolic process IMP
 biological_processGO:0046513 ceramide biosynthetic process IMP
 biological_processGO:0071466 cellular response to xenobiotic stimulus IMP
 biological_processGO:0071502 cellular response to temperature stimulus IDA
 biological_processGO:0090520 sphingolipid mediated signaling pathway IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IMP


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000051920 nsmaf / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / complex / reaction
 ENSDARG00000041619 rack1 / O42248 / receptor for activated C kinase 1 / P68040* / P63244* / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed*  / reaction / complex






 

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