ENSG00000006062


Homo sapiens

Features
Gene ID: ENSG00000006062
  
Biological name :MAP3K14
  
Synonyms : MAP3K14 / mitogen-activated protein kinase kinase kinase 14 / Q99558
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 45263121
Gene end: 45317040
  
Corresponding Affymetrix probe sets: 205192_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480974
Ensembl peptide - ENSP00000482657
Ensembl peptide - ENSP00000478552
NCBI entrez gene - 9020     See in Manteia.
OMIM - 604655
RefSeq - NM_003954
RefSeq - XM_011525441
RefSeq Peptide - NP_003945
swissprot - A0A087WXF1
swissprot - Q99558
Ensembl - ENSG00000006062
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arf2bENSDARG00000056582Danio rerio
 map3k14aENSDARG00000074060Danio rerio
 MAP3K14ENSGALG00000000685Gallus gallus
 Q9WUL6ENSMUSG00000020941Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q56UN5 / MAP3K19 / mitogen-activated protein kinase kinase kinase 19ENSG0000017660115
MAP3K2 / Q9Y2U5 / mitogen-activated protein kinase kinase kinase 2ENSG0000016996715
MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1ENSG0000009501514
MAP3K3 / Q99759 / mitogen-activated protein kinase kinase kinase 3ENSG0000019890913
MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8ENSG0000010796812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017425  Mitogen-activated protein (MAP) kinase kinase kinase 14
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity EXP
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / reaction / complex
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / reaction
 ENSG00000159958 Q96RJ3 / TNFRSF13C / TNF receptor superfamily member 13C  / complex / reaction
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / complex / reaction
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / complex / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / reaction / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000120659 O14788 / TNFSF11 / TNF superfamily member 11  / complex / reaction
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / reaction / complex
 ENSG00000141655 Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11a  / complex / reaction
 ENSG00000101017 CD40 / P25942 / CD40 molecule  / complex / reaction
 ENSG00000102245 CD40LG / P29965 / CD40 ligand  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / reaction / complex
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000102524 Q9Y275 / TNFSF13B / TNF superfamily member 13b  / reaction / complex
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / reaction / complex
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr