ENSDARG00000074060


Danio rerio

Features
Gene ID: ENSDARG00000074060
  
Biological name :map3k14a
  
Synonyms : map3k14a / mitogen-activated protein kinase kinase kinase 14a
  
Possible biological names infered from orthology : MAP3K14 / mitogen-activated protein kinase kinase kinase 14 / Q99558 / Q9WUL6
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 37707432
Gene end: 37742595
  
Corresponding Affymetrix probe sets: Dr.16747.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000125811
NCBI entrez gene - 100004261     See in Manteia.
RefSeq - XM_002661208
swissprot - E7FEY1
ZFIN ID - ZDB-GENE-120215-80
Ensembl - ENSDARG00000074060
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K14ENSGALG00000000685Gallus gallus
 Q99558ENSG00000006062Homo sapiens
 Q9WUL6ENSMUSG00000020941Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arf2b / map3k14b / mitogen-activated protein kinase kinase kinase 14b / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*ENSDARG0000005658232
map3k1 / mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase / Q13233* / mitogen-activated protein kinase kinase kinase 1*ENSDARG0000009840512
map3k3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*ENSDARG0000006034812
map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*ENSDARG0000006171012
map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSDARG0000006288411
map3k19 / mitogen-activated protein kinase kinase kinase 19 / E9Q3S4* / Q56UN5*ENSDARG000000942729
map3k20 / mitogen-activated protein kinase kinase kinase 20ENSDARG000000742192


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017425  Mitogen-activated protein (MAP) kinase kinase kinase 14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000061710 map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / reaction / complex
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSDARG00000068141 tnfsf11 / TNF superfamily member 11 / O14788* / O35235* / tumor necrosis factor (ligand) superfamily, member 11*  / complex / reaction
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSDARG00000087804 tnfrsf11a / tumor necrosis factor receptor superfamily, member 11a, NFKB activator / CD40* / Q9Y6Q6* / O35305* / P25942* / P27512* / CD40 molecule* / TNF receptor superfamily member 11a* / ...  / complex / reaction
 ENSDARG00000054968 cd40 / CD40 molecule, TNF receptor superfamily member 5 / P27512* / O35305* / P25942* / Q9Y6Q6* / TNFRSF11A* / CD40 molecule* / TNF receptor superfamily member 11a* / Tumor necrosis factor ...  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000012945 tnfsf13b / TNF superfamily member 13b / Q9Y275*  / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex






 

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