ENSDARG00000044619


Danio rerio

Features
Gene ID: ENSDARG00000044619
  
Biological name :birc2
  
Synonyms : baculoviral IAP repeat containing 2 / birc2
  
Possible biological names infered from orthology : baculoviral IAP repeat containing 3 / Baculoviral IAP repeat-containing protein 2 / BIRC3 / Q13489 / Q13490 / Q62210
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 22833905
Gene end: 22851230
  
Corresponding Affymetrix probe sets: Dr.2849.1.S1_at (Zebrafish Array)   NM_194395_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000151933
Ensembl peptide - ENSDARP00000065554
Ensembl peptide - ENSDARP00000103254
Ensembl peptide - ENSDARP00000126110
NCBI entrez gene - 373107     See in Manteia.
RefSeq - NM_194395
RefSeq - XM_005161156
RefSeq - XM_017352755
RefSeq Peptide - NP_919376
swissprot - Q7T0K2
swissprot - A0A0R4I9H2
ZFIN ID - ZDB-GENE-030825-6
Ensembl - ENSDARG00000044619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BIRC2ENSGALG00000017186Gallus gallus
 BIRC2ENSG00000110330Homo sapiens
 BIRC3ENSG00000023445Homo sapiens
 Birc2ENSMUSG00000057367Mus musculus
 Birc3ENSMUSG00000032000Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
xiap / X-linked inhibitor of apoptosis / BIRC8* / Q60989* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*ENSDARG0000001614324
birc7 / baculoviral IAP repeat containing 7 / A2AWP0* / Q96CA5* / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit*ENSDARG0000005808223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type
 IPR011029  Death-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood mislocalised , abnormal
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 ZFA:0000008 brain brain necrotic , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta blood vessel endothelial cell apoptotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein blood vessel endothelial cell apoptotic , abnormal
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 ZFA:0001079 blood vasculature blood vasculature degenerate , abnormal
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 ZFA:0001114 head head color , abnormal
head necrotic , abnormal
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 ZFA:0001115 trunk trunk degenerate , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased diameter , abnormal
intersegmental vessel blood circulation absent , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell apoptotic , abnormal
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 ZFA:0009065 endothelial cell endothelial cell apoptotic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000054968 cd40 / CD40 molecule, TNF receptor superfamily member 5 / P27512* / O35305* / P25942* / Q9Y6Q6* / TNFRSF11A* / CD40 molecule* / TNF receptor superfamily member 11a* / Tumor necrosis factor ...  / reaction / complex
 ENSDARG00000087804 tnfrsf11a / tumor necrosis factor receptor superfamily, member 11a, NFKB activator / CD40* / Q9Y6Q6* / O35305* / P25942* / P27512* / CD40 molecule* / TNF receptor superfamily member 11a* / ...  / reaction / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / reaction / complex
 ENSDARG00000068141 tnfsf11 / TNF superfamily member 11 / O14788* / O35235* / tumor necrosis factor (ligand) superfamily, member 11*  / complex / reaction
 ENSDARG00000012945 tnfsf13b / TNF superfamily member 13b / Q9Y275*  / complex
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / reaction / complex
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex / reaction
 ENSDARG00000004132 usp19 / ubiquitin specific peptidase 19 / O94966* / Q3UJD6*  / complex / reaction






 

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