ENSMUSG00000032000


Mus musculus

Features
Gene ID: ENSMUSG00000032000
  
Biological name :Birc3
  
Synonyms : baculoviral IAP repeat containing 3 / Birc3
  
Possible biological names infered from orthology : Q13489
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A1
Gene start: 7848699
Gene end: 7873186
  
Corresponding Affymetrix probe sets: 10590801 (MoGene1.0st)   1421392_a_at (Mouse Genome 430 2.0 Array)   1425223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125652
Ensembl peptide - ENSMUSP00000013949
Ensembl peptide - ENSMUSP00000111336
Ensembl peptide - ENSMUSP00000111337
Ensembl peptide - ENSMUSP00000125512
NCBI entrez gene - 11796     See in Manteia.
MGI - MGI:1197007
RefSeq - XM_011242353
RefSeq - NM_007464
RefSeq - XM_006509828
RefSeq - XM_006509829
RefSeq - XM_006509830
RefSeq - XM_006509831
RefSeq - XM_011242352
RefSeq Peptide - NP_031490
swissprot - E0CZ68
swissprot - E0CZ20
swissprot - F7BQL8
swissprot - A2CGA5
swissprot - A2CGA3
Ensembl - ENSMUSG00000032000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 birc2ENSDARG00000044619Danio rerio
 BIRC2ENSGALG00000017186Gallus gallus
 BIRC3ENSG00000023445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*ENSMUSG0000005736768
Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*ENSMUSG0000002586030
Naip5 / NLR family, apoptosis inhibitory protein 5 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007120323
Naip6 / Q9JIB6 / NLR family, apoptosis inhibitory protein 6 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894223
Naip2 / Q9QUK4 / NLR family, apoptosis inhibitory protein 2 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894523
Naip1 / Q9QWK5 / NLR family, apoptosis inhibitory protein 1 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000002164023
Birc7 / A2AWP0 / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit / Q96CA5* / baculoviral IAP repeat containing 7*ENSMUSG0000003884019
Nlrc4 / Q3UP24 / NLR family CARD domain-containing protein 4 / Q9NPP4* / NLR family CARD domain containing 4*ENSMUSG000000391939


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type
 IPR011029  Death-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060544 regulation of necroptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1Rbr/Birc3tm1Rbr
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Birc3tm1.1Rbr/Birc3tm1.1Rbr,Xiaptm1Vdr/Xiaptm1Vdr
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0008656 abnormal interleukin-1 beta secretion "anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008662 abnormal interleukin-12 secretion "anomaly in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1tm1Led
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Birc2tm1.1Rbr/Birc2tm1.1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Ripk1tm1Led/Ripk1+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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