ENSMUSG00000071203


Mus musculus

Features
Gene ID: ENSMUSG00000071203
  
Biological name :Naip5
  
Synonyms : Naip5 / NLR family, apoptosis inhibitory protein 5
  
Possible biological names infered from orthology : NAIP / NLR family apoptosis inhibitory protein / Q13075
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 100211739
Gene end: 100246323
  
Corresponding Affymetrix probe sets: 10411611 (MoGene1.0st)   1421525_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058611
NCBI entrez gene - 17951     See in Manteia.
MGI - MGI:1298220
RefSeq - XM_017315417
RefSeq - NM_010870
RefSeq - XM_017315415
RefSeq - XM_017315416
RefSeq - XM_011244628
RefSeq - XM_011244631
RefSeq - XM_011244633
RefSeq Peptide - NP_035000
swissprot - Q8CGT2
Ensembl - ENSMUSG00000071203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NAIPENSG00000249437Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Naip6 / Q9JIB6 / NLR family, apoptosis inhibitory protein 6 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894295
Naip1 / Q9QWK5 / NLR family, apoptosis inhibitory protein 1 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000002164087
Naip2 / Q9QUK4 / NLR family, apoptosis inhibitory protein 2 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894583
Nlrc4 / Q3UP24 / NLR family CARD domain-containing protein 4 / Q9NPP4* / NLR family CARD domain containing 4*ENSMUSG0000003919316
Birc3 / baculoviral IAP repeat containing 3 / Q13489*ENSMUSG0000003200010
Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*ENSMUSG0000005736710
Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*ENSMUSG000000258609
Birc7 / A2AWP0 / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit / Q96CA5* / baculoviral IAP repeat containing 7*ENSMUSG000000388405


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028789  Baculoviral IAP repeat-containing protein 1
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnmt1tm1Okan/Dnmt1tm2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

Allelic Composition: Naip5m1Btlr/Naip5m1Btlr
Genetic Background: C57BL/6J-Naip5m1Btlr

Allelic Composition: Naip5m2Btlr/Naip5m2Btlr
Genetic Background: C57BL/6J-Naip5m2Btlr

Allelic Composition: Naip5m2Btlr/Naip5+
Genetic Background: C57BL/6J-Naip5m2Btlr

 MP:0012555 decreased cell death "decreased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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