ENSMUSG00000039193


Mus musculus

Features
Gene ID: ENSMUSG00000039193
  
Biological name :Nlrc4
  
Synonyms : Nlrc4 / NLR family CARD domain-containing protein 4 / Q3UP24
  
Possible biological names infered from orthology : NLR family CARD domain containing 4 / Q9NPP4
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E2
Gene start: 74426295
Gene end: 74459108
  
Corresponding Affymetrix probe sets: 10452879 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000059637
NCBI entrez gene - 268973     See in Manteia.
MGI - MGI:3036243
RefSeq - XM_017317491
RefSeq - NM_001033367
RefSeq - XM_006524347
RefSeq - XM_017317490
RefSeq - XM_006524346
RefSeq Peptide - NP_001028539
swissprot - Q3UP24
Ensembl - ENSMUSG00000039193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NLRC4ENSG00000091106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Naip2 / Q9QUK4 / NLR family, apoptosis inhibitory protein 2 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894522
Naip1 / Q9QWK5 / NLR family, apoptosis inhibitory protein 1 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000002164022
Naip6 / Q9JIB6 / NLR family, apoptosis inhibitory protein 6 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894221
Naip5 / NLR family, apoptosis inhibitory protein 5 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007120321
Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*ENSMUSG000000573677
Birc3 / baculoviral IAP repeat containing 3 / Q13489*ENSMUSG000000320006
Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*ENSMUSG000000258604
Birc7 / A2AWP0 / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit / Q96CA5* / baculoviral IAP repeat containing 7*ENSMUSG000000388403


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0016045 detection of bacterium IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050702 interleukin-1 beta secretion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0070269 pyroptosis IMP
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0072557 IPAF inflammasome complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nlrc4tm1Gln/Nlrc4tm1Gln,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrc4tm1Gln

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

Allelic Composition: Nlrc4m1Btlr/Nlrc4m1Btlr
Genetic Background: C57BL/6J-Nlrc4m1Btlr

Allelic Composition: Nlrc4m1Btlr/Nlrc4+
Genetic Background: C57BL/6J-Nlrc4m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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