ENSG00000249437


Homo sapiens

Features
Gene ID: ENSG00000249437
  
Biological name :NAIP
  
Synonyms : NAIP / NLR family apoptosis inhibitory protein / Q13075
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q13.2
Gene start: 70968483
Gene end: 71025114
  
Corresponding Affymetrix probe sets: 204860_s_at (Human Genome U133 Plus 2.0 Array)   204861_s_at (Human Genome U133 Plus 2.0 Array)   238446_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429154
Ensembl peptide - ENSP00000443944
Ensembl peptide - ENSP00000429591
Ensembl peptide - ENSP00000429545
Ensembl peptide - ENSP00000424913
Ensembl peptide - ENSP00000428226
Ensembl peptide - ENSP00000428363
Ensembl peptide - ENSP00000428657
NCBI entrez gene - 4671     See in Manteia.
OMIM - 600355
RefSeq - NM_001346870
RefSeq - NM_004536
RefSeq - NM_022892
RefSeq Peptide - NP_004527
RefSeq Peptide - NP_075043
RefSeq Peptide - NP_001333799
swissprot - Q13075
swissprot - E5RJA3
swissprot - H0YAX2
swissprot - E7EQW0
Ensembl - ENSG00000249437
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Naip1ENSMUSG00000021640Mus musculus
 Naip2ENSMUSG00000078945Mus musculus
 Naip5ENSMUSG00000071203Mus musculus
 Naip6ENSMUSG00000078942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLRC4 / Q9NPP4 / NLR family CARD domain containing 4ENSG0000009110617
BIRC2 / Q13490 / baculoviral IAP repeat containing 2ENSG0000011033011
BIRC3 / Q13489 / baculoviral IAP repeat containing 3ENSG0000002344510
XIAP / P98170 / X-linked inhibitor of apoptosisENSG000001019668
BIRC7 / Q96CA5 / baculoviral IAP repeat containing 7ENSG000001011974
BIRC8 / Q96P09 / baculoviral IAP repeat containing 8ENSG000001630984


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat
 IPR003593  AAA+ ATPase domain
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028789  Baculoviral IAP repeat-containing protein 1
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IBA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IMP
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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