ENSDARG00000070165


Danio rerio

Features
Gene ID: ENSDARG00000070165
  
Biological name :tnfrsf1b
  
Synonyms : tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B
  
Possible biological names infered from orthology : P20333 / P25119 / TNF receptor superfamily member 1B
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 40431629
Gene end: 40457325
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000104953
NCBI entrez gene - 100037357     See in Manteia.
swissprot - F1RAS9
ZFIN ID - ZDB-GENE-070410-133
Ensembl - ENSDARG00000070165
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFRSF1BENSGALG00000034213Gallus gallus
 P20333ENSG00000028137Homo sapiens
 P25119ENSMUSG00000028599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnfrsf21 / tumor necrosis factor receptor superfamily, member 21 / O75509* / Q9EPU5* / TNF receptor superfamily member 21*ENSDARG0000000180720
tnfrsf11a / tumor necrosis factor receptor superfamily, member 11a, NFKB activator / CD40* / Q9Y6Q6* / O35305* / P25942* / P27512* / CD40 molecule* / TNF receptor superfamily member 11a* / ...ENSDARG0000008780419
cd40 / CD40 molecule, TNF receptor superfamily member 5 / P27512* / O35305* / P25942* / Q9Y6Q6* / TNFRSF11A* / CD40 molecule* / TNF receptor superfamily member 11a* / Tumor necrosis factor ...ENSDARG0000005496817
si:dkey-23c22.5 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000009289214
zgc:153631 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000006899314
zgc:153759 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000006896914
si:dkey-23c22.7 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000009519313
zgc:153759 / si:dkey-23c22.9 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000009238113
tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b / O95407* / O00300* / O08712* / TNFRSF6B* / TNF receptor superfamily member 6b* / TNF receptor superfamily member 11b* / t...ENSDARG0000009837713
si:ch211-261n11.7 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000006896613
si:ch211-261n11.8 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG0000008990112
CT737125.1 / Q92956* / TNFRSF14* / TNF receptor superfamily member 14* / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)*ENSDARG000000689919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IGI
 biological_processGO:1901534 positive regulation of hematopoietic progenitor cell differentiation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000011 caudal artery caudal artery poorly differentiated , abnormal
Show

 ZFA:0000180 caudal vein caudal vein malformed , abnormal
caudal vein poorly differentiated , abnormal
Show

 ZFA:0001094 whole organism whole organism hemorrhagic , abnormal
whole organism life span , ameliorated
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell increased amount , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell apoptotic , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased accumulation caudal artery , abnormal
nucleate erythrocyte increased accumulation dorsal aorta , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / reaction / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex / reaction
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / reaction / complex
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex / reaction
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / reaction / complex






 

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