ENSDARG00000022000


Danio rerio

Features
Gene ID: ENSDARG00000022000
  
Biological name :traf3
  
Synonyms : TNF receptor-associated factor 3 / traf3
  
Possible biological names infered from orthology : Q13114 / Q60803
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 29227502
Gene end: 29249258
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000038596
NCBI entrez gene - 445119     See in Manteia.
RefSeq - NM_001003513
RefSeq Peptide - NP_001003513
swissprot - Q6DEG0
ZFIN ID - ZDB-GENE-040801-257
Ensembl - ENSDARG00000022000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRAF3ENSGALG00000011389Gallus gallus
 TRAF3ENSG00000131323Homo sapiens
 Traf3ENSMUSG00000021277Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*ENSDARG0000003017330
traf2b / Tnf receptor-associated factor 2bENSDARG0000010103630
traf1 / TNF receptor-associated factor 1 / P39428* / Q13077*ENSDARG0000006948227
traf4a / tnf receptor-associated factor 4a / TRAF4* / Q61382* / Q9BUZ4* / TNF receptor associated factor 4*ENSDARG0000000396324
traf4b / tnf receptor-associated factor 4bENSDARG0000003896423
traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*ENSDARG0000002805822
unm_sa808 / un-named sa808 / TRAF2* / Q12933* / TNF receptor associated factor 2*ENSDARG0000007837820
traf5 / Tnf receptor-associated factor 5 / O00463*ENSDARG0000001724015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027128  TNF receptor-associated factor 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0001878 response to yeast IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / reaction / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / reaction / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex
 ENSDARG00000087804 tnfrsf11a / tumor necrosis factor receptor superfamily, member 11a, NFKB activator / CD40* / Q9Y6Q6* / O35305* / P25942* / P27512* / CD40 molecule* / TNF receptor superfamily member 11a* / ...  / reaction / complex
 ENSDARG00000054968 cd40 / CD40 molecule, TNF receptor superfamily member 5 / P27512* / O35305* / P25942* / Q9Y6Q6* / TNFRSF11A* / CD40 molecule* / TNF receptor superfamily member 11a* / Tumor necrosis factor ...  / complex / reaction
 ENSDARG00000068141 tnfsf11 / TNF superfamily member 11 / O14788* / O35235* / tumor necrosis factor (ligand) superfamily, member 11*  / complex / reaction
 ENSDARG00000012945 tnfsf13b / TNF superfamily member 13b / Q9Y275*  / complex
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / reaction / complex
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex






 

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