ENSDARG00000103095


Danio rerio

Features
Gene ID: ENSDARG00000103095
  
Biological name :tbk1
  
Synonyms : TANK-binding kinase 1 / tbk1
  
Possible biological names infered from orthology : Q9UHD2 / Q9WUN2
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 134412
Gene end: 149334
  
Corresponding Affymetrix probe sets: Dr.19385.1.S1_at (Zebrafish Array)   Dr.19385.2.A1_at (Zebrafish Array)   NM_001044748_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000132718
NCBI entrez gene - 692289     See in Manteia.
RefSeq - XM_021475140
RefSeq - NM_001044748
RefSeq Peptide - NP_001038213
swissprot - Q0GKD6
ZFIN ID - ZDB-GENE-060512-359
Ensembl - ENSDARG00000103095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TBK1ENSGALG00000009840Gallus gallus
 TBK1ENSG00000183735Homo sapiens
 Tbk1ENSMUSG00000020115Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*ENSDARG0000007060644
chuk / conserved helix-loop-helix ubiquitous kinase / O15111*ENSDARG0000001166220
ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*ENSDARG0000007912319
ulk2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSDARG0000009720518
ulk1a / unc-51 like autophagy activating kinase 1a / ULK1* / O75385* / unc-51 like kinase 1* / unc-51 like autophagy activating kinase 1*ENSDARG0000006251817
ulk1b / unc-51 like autophagy activating kinase 1 / ULK1* / O75385* / unc-51 like kinase 1*ENSDARG0000007448117
ulk3 / unc-51 like kinase 3 / Q6PHR2*ENSDARG000001016618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Interleukin-37 signaling
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / reaction / complex
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / reaction / complex
 ENSDARG00000091058 tmem173 / transmembrane protein 173 / Q3TBT3* / Q86WV6* / Stimulator of interferons protein *  / complex / reaction
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000015902 stat6 / signal transducer and activator of transcription 6, interleukin-4 induced / P42226* / P52633* / Signal transducer and transcription activator 6 * / signal transducer and activator o...  / reaction / complex
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000076302 DTX4 / si:ch211-119e14.2 / Q6PDK8* / Q9Y2E6* / deltex E3 ubiquitin ligase 4* / E3 ubiquitin-protein ligase DTX4 *  / reaction / complex
 ENSDARG00000078016 dtx4 / deltex 4, E3 ubiquitin ligase / Q9Y2E6* / Q6PDK8* / deltex E3 ubiquitin ligase 4* / E3 ubiquitin-protein ligase DTX4 *  / complex / reaction
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex
 ENSDARG00000027777 tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / Q60769* / TNF alpha induced protein 3*  / complex / reaction






 

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