ENSDARG00000045661


Danio rerio

Features
Gene ID: ENSDARG00000045661
  
Biological name :irf7
  
Synonyms : interferon regulatory factor 7 / irf7
  
Possible biological names infered from orthology : P70434 / Q92985
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 25546789
Gene end: 25550955
  
Corresponding Affymetrix probe sets: Dr.10428.1.S1_at (Zebrafish Array)   NM_200677_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000094398
Ensembl peptide - ENSDARP00000125556
NCBI entrez gene - 393650     See in Manteia.
RefSeq - NM_001313779
RefSeq - NM_200677
RefSeq Peptide - NP_001300708
RefSeq Peptide - NP_956971
swissprot - F1QNG2
swissprot - H0WFC4
ZFIN ID - ZDB-GENE-040426-1518
Ensembl - ENSDARG00000045661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRF7ENSGALG00000014297Gallus gallus
 IRF7ENSG00000185507Homo sapiens
 Irf7ENSMUSG00000025498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irf5 / interferon regulatory factor 5 / P56477* / Q13568*ENSDARG0000004568125
irf3 / interferon regulatory factor 3 / P70671* / Q14653*ENSDARG0000007625125
irf6 / interferon regulatory factor 6 / O14896* / P97431*ENSDARG0000010198624
irf8 / interferon regulatory factor 8 / P23611* / Q02556*ENSDARG0000005640720
irf4a / interferon regulatory factor 4a / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000000656020
irf9 / interferon regulatory factor 9 / Q00978* / Q61179*ENSDARG0000001645720
irf4b / interferon regulatory factor 4b / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000005537419
irf10 / interferon regulatory factor 10ENSDARG0000002765819
irf1b / interferon regulatory factor 1b / IRF1* / P10914* / interferon regulatory factor 1*ENSDARG0000004324911
irf2 / interferon regulatory factor 2 / P14316* / P23906*ENSDARG0000004046511
irf2a / interferon regulatory factor 2aENSDARG0000000738711
irf1a / interferon regulatory factor 1aENSDARG0000004349210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0045580 regulation of T cell differentiation IGI
 biological_processGO:1902037 negative regulation of hematopoietic stem cell differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IGI


Pathways (from Reactome)
Pathway description
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / reaction / complex
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / reaction / complex
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex / reaction
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / reaction / complex
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex / reaction
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / reaction / complex
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex / reaction
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / reaction / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / reaction / complex
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex / reaction






 

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