ENSDARG00000006560


Danio rerio

Features
Gene ID: ENSDARG00000006560
  
Biological name :irf4a
  
Synonyms : interferon regulatory factor 4a / irf4a
  
Possible biological names infered from orthology : interferon regulatory factor 4 / IRF4 / Q15306 / Q64287
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 854444
Gene end: 879800
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000005897
NCBI entrez gene - 100002070     See in Manteia.
RefSeq - NM_001122710
RefSeq Peptide - NP_001116182
swissprot - A8B8L1
ZFIN ID - ZDB-GENE-070912-330
Ensembl - ENSDARG00000006560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000043913Gallus gallus
 IRF4ENSGALG00000012830Gallus gallus
 IRF4ENSG00000137265Homo sapiens
 Irf4ENSMUSG00000021356Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irf4b / interferon regulatory factor 4b / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000005537453
irf10 / interferon regulatory factor 10ENSDARG0000002765837
irf8 / interferon regulatory factor 8 / P23611* / Q02556*ENSDARG0000005640734
irf9 / interferon regulatory factor 9 / Q00978* / Q61179*ENSDARG0000001645729
irf6 / interferon regulatory factor 6 / O14896* / P97431*ENSDARG0000010198626
irf5 / interferon regulatory factor 5 / P56477* / Q13568*ENSDARG0000004568124
irf7 / interferon regulatory factor 7 / P70434* / Q92985*ENSDARG0000004566118
irf3 / interferon regulatory factor 3 / P70671* / Q14653*ENSDARG0000007625118
irf1a / interferon regulatory factor 1aENSDARG0000004349214
irf2 / interferon regulatory factor 2 / P14316* / P23906*ENSDARG0000004046514
irf2a / interferon regulatory factor 2aENSDARG0000000738713
irf1b / interferon regulatory factor 1b / IRF1* / P10914* / interferon regulatory factor 1*ENSDARG0000004324913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0097535 lymphoid lineage cell migration into thymus IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm leukocyte increased amount , abnormal
intermediate cell mass of mesoderm macrophage increased amount , abnormal
intermediate cell mass of mesoderm neutrophil increased amount , abnormal
intermediate cell mass of mesoderm decreased distribution , abnormal
intermediate cell mass of mesoderm decreased amount , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0001077 thymus primordium thymus primordium absent , abnormal
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 ZFA:0001078 thymus thymus absent , abnormal
thymus leukocyte decreased distribution , abnormal
thymus leukocyte decreased amount , abnormal
thymus hematopoietic stem cell migration decreased occurrence , abnormal
thymus T cell absent , abnormal
thymus hematopoietic multipotent progenitor cell decreased amount , abnormal
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 ZFA:0005023 hematopoietic system hematopoietic system leukocyte increased amount , abnormal
hematopoietic system increased amount , abnormal
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 ZFA:0009141 macrophage macrophage increased distribution , abnormal
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 ZFA:0009327 neutrophil neutrophil increased distribution , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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