ENSG00000137265


Homo sapiens

Features
Gene ID: ENSG00000137265
  
Biological name :IRF4
  
Synonyms : interferon regulatory factor 4 / IRF4 / Q15306
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p25.3
Gene start: 391739
Gene end: 411447
  
Corresponding Affymetrix probe sets: 204562_at (Human Genome U133 Plus 2.0 Array)   216986_s_at (Human Genome U133 Plus 2.0 Array)   216987_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370343
Ensembl peptide - ENSP00000436094
NCBI entrez gene - 3662     See in Manteia.
OMIM - 601900
RefSeq - XM_006715090
RefSeq - NM_001195286
RefSeq - NM_002460
RefSeq Peptide - NP_001182215
RefSeq Peptide - NP_002451
swissprot - Q15306
swissprot - F2Z3D5
Ensembl - ENSG00000137265
  
Related genetic diseases (OMIM): 611724 - [Skin/hair/eye pigmentation, variation in, 8], 611724

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf4aENSDARG00000006560Danio rerio
 irf4bENSDARG00000055374Danio rerio
 ENSGALG00000043913Gallus gallus
 IRF4ENSGALG00000012830Gallus gallus
 Irf4ENSMUSG00000021356Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRF8 / Q02556 / interferon regulatory factor 8ENSG0000014096842
IRF5 / Q13568 / interferon regulatory factor 5ENSG0000012860430
IRF9 / Q00978 / interferon regulatory factor 9ENSG0000021392829
IRF6 / O14896 / interferon regulatory factor 6ENSG0000011759527
IRF7 / Q92985 / interferon regulatory factor 7ENSG0000018550723
IRF3 / Q14653 / interferon regulatory factor 3ENSG0000012645620
IRF2 / P14316 / interferon regulatory factor 2ENSG0000016831017
IRF1 / P10914 / interferon regulatory factor 1ENSG0000012534715


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0018022 peptidyl-lysine methylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0042832 defense response to protozoan IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045082 positive regulation of interleukin-10 biosynthetic process IDA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IDA
 biological_processGO:0045368 positive regulation of interleukin-13 biosynthetic process IDA
 biological_processGO:0045404 positive regulation of interleukin-4 biosynthetic process IDA
 biological_processGO:0045622 regulation of T-helper cell differentiation NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0072540 T-helper 17 cell lineage commitment IEA
 cellular_componentGO:0000788 nuclear nucleosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding NAS
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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