ENSDARG00000056407


Danio rerio

Features
Gene ID: ENSDARG00000056407
  
Biological name :irf8
  
Synonyms : interferon regulatory factor 8 / irf8
  
Possible biological names infered from orthology : P23611 / Q02556
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 30567945
Gene end: 30573849
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000073353
NCBI entrez gene - 436895     See in Manteia.
RefSeq - NM_001002622
RefSeq Peptide - NP_001002622
swissprot - Q6DHK7
ZFIN ID - ZDB-GENE-040718-367
Ensembl - ENSDARG00000056407
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRF8ENSGALG00000005757Gallus gallus
 IRF8ENSG00000140968Homo sapiens
 Irf8ENSMUSG00000041515Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irf4a / interferon regulatory factor 4a / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000000656037
irf10 / interferon regulatory factor 10ENSDARG0000002765833
irf4b / interferon regulatory factor 4b / IRF4* / Q15306* / Q64287* / interferon regulatory factor 4*ENSDARG0000005537432
irf9 / interferon regulatory factor 9 / Q00978* / Q61179*ENSDARG0000001645731
irf5 / interferon regulatory factor 5 / P56477* / Q13568*ENSDARG0000004568128
irf6 / interferon regulatory factor 6 / O14896* / P97431*ENSDARG0000010198627
irf7 / interferon regulatory factor 7 / P70434* / Q92985*ENSDARG0000004566120
irf3 / interferon regulatory factor 3 / P70671* / Q14653*ENSDARG0000007625119
irf2a / interferon regulatory factor 2aENSDARG0000000738716
irf2 / interferon regulatory factor 2 / P14316* / P23906*ENSDARG0000004046514
irf1a / interferon regulatory factor 1aENSDARG0000004349213
irf1b / interferon regulatory factor 1b / IRF1* / P10914* / interferon regulatory factor 1*ENSDARG0000004324913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002573 myeloid leukocyte differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0014005 microglia development IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0045649 regulation of macrophage differentiation IMP
 biological_processGO:0045658 regulation of neutrophil differentiation IMP
 biological_processGO:0061515 myeloid cell development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood amount , ameliorated
Show

 ZFA:0000008 brain brain lacks all parts of type microglial cell , abnormal
Show

 ZFA:0000029 hindbrain hindbrain amount , ameliorated
Show

 ZFA:0000094 blood island blood island macrophage absent , abnormal
blood island macrophage decreased amount , abnormal
blood island cell death increased process quality , abnormal
Show

 ZFA:0000123 liver liver increased size , abnormal
liver neutrophil increased amount , abnormal
Show

 ZFA:0000128 midbrain midbrain amount , ameliorated
Show

 ZFA:0000243 neuromast neuromast epithelium position , ameliorated
Show

 ZFA:0000445 optic tectum optic tectum apoptotic cell clearance decreased occurrence , abnormal
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium position , ameliorated
Show

 ZFA:0001058 caudal fin caudal fin regenerating fin increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism decreased life span , exacerbated
whole organism lacks all parts of type macrophage , abnormal
whole organism has fewer parts of type macrophage , abnormal
whole organism has extra parts of type neutrophil , abnormal
Show

 ZFA:0001114 head head macrophage absent , abnormal
head macrophage decreased amount , abnormal
head epidermis position , ameliorated
Show

 ZFA:0001115 trunk trunk amount , ameliorated
Show

 ZFA:0001269 regenerating fin regenerating fin apoptotic process occurrence , ameliorated
regenerating fin apoptotic process increased occurrence , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature morphology , ameliorated
trunk vasculature response to bacterium process quality , abnormal
Show

 ZFA:0005249 vasculature vasculature amount , ameliorated
Show

 ZFA:0009034 epithelial cell epithelial cell position , ameliorated
Show

 ZFA:0009077 microglial cell microglial cell decreased amount , abnormal
microglial cell absent , abnormal
Show

 ZFA:0009114 muscle cell muscle cell cell wall repair process quality , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased amount , abnormal
macrophage aplastic , abnormal
macrophage immature , abnormal
macrophage absent , abnormal
macrophage amount , ameliorated
Show

 ZFA:0009159 mucus secreting cell mucus secreting cell decreased amount , abnormal
mucus secreting cell proliferative , abnormal
Show

 ZFA:0009163 myelin accumulating cell myelin accumulating cell cell projection amount , ameliorated
Show

 ZFA:0009248 neuron neuron myelin sheath disorganized , ameliorated
Show

 ZFA:0009324 myeloid cell myeloid cell cell death increased process quality , abnormal
Show

 ZFA:0009327 neutrophil neutrophil increased amount , abnormal
neutrophil response to wounding process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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