ENSMUSG00000041515


Mus musculus

Features
Gene ID: ENSMUSG00000041515
  
Biological name :Irf8
  
Synonyms : interferon regulatory factor 8 / Irf8 / P23611
  
Possible biological names infered from orthology : Q02556
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 120736358
Gene end: 120756694
  
Corresponding Affymetrix probe sets: 10576034 (MoGene1.0st)   1416714_at (Mouse Genome 430 2.0 Array)   1448452_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125447
Ensembl peptide - ENSMUSP00000040245
Ensembl peptide - ENSMUSP00000125029
Ensembl peptide - ENSMUSP00000125443
NCBI entrez gene - 15900     See in Manteia.
MGI - MGI:96395
RefSeq - NM_001301811
RefSeq - NM_008320
RefSeq Peptide - NP_001288740
RefSeq Peptide - NP_032346
swissprot - Q544J7
swissprot - E0CZE4
swissprot - P23611
swissprot - F7C1A3
Ensembl - ENSMUSG00000041515
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf8ENSDARG00000056407Danio rerio
 IRF8ENSGALG00000005757Gallus gallus
 IRF8ENSG00000140968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135644
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977132
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232531
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663831
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549822
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318420
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162718
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0006955 immune response IMP
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IPI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071346 cellular response to interferon-gamma ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BXH2/TyJ * C3H/HeJ

Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm
Genetic Background: involves: 129S6/SvEvTac

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: A/J * BXH2/TyJ

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a4loop/Slc26a4loop
Genetic Background: C3HeB/FeJ-Slc26a4loop

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1s
Genetic Background: involves: BXH2/TyJ * C57BL/6J

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BXH2/TyJ * C57BL/6J

Allelic Composition: Irf8myls/Irf8myls,Slc11a1s/Slc11a1s
Genetic Background: involves: BALB/cJ * BXH2/TyJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1s
Genetic Background: involves: BALB/cJ * BXH2/TyJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BALB/cJ * BXH2/TyJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: BXH2/TyJ * C3H/HeJ

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8myls/Irf8+
Genetic Background: involves: BXH2/TyJ * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Irf8tm1Hor/Irf8+
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: involves: A/J * BXH2/TyJ

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008096 abnormal plasma cell number "anomaly in the number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf8tm1Hor/Irf8tm1Hor,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8myls/Irf8+
Genetic Background: involves: BXH2/TyJ * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8myls/Irf8+
Genetic Background: involves: BXH2/TyJ * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor
Genetic Background: B6.129P2-Irf8tm1Hor

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8tm1Hor/Irf8tm1Hor
Genetic Background: B6.129P2-Irf8tm1Hor

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Irf8myls/Irf8+
Genetic Background: involves: BXH2/TyJ * C57BL/6

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Irf8myls/Irf8myls,Slc11a1r/Slc11a1r
Genetic Background: BXH2/TyJ-Irf8myls

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Hoxc13tm2Mrc/Hoxc13tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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