ENSMUSG00000029771


Mus musculus

Features
Gene ID: ENSMUSG00000029771
  
Biological name :Irf5
  
Synonyms : Interferon regulatory factor 5 / Irf5 / P56477
  
Possible biological names infered from orthology : Q13568
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.3
Gene start: 29526625
Gene end: 29541871
  
Corresponding Affymetrix probe sets: 10536898 (MoGene1.0st)   1449678_at (Mouse Genome 430 2.0 Array)   1460231_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004392
Ensembl peptide - ENSMUSP00000127021
Ensembl peptide - ENSMUSP00000130548
Ensembl peptide - ENSMUSP00000145299
Ensembl peptide - ENSMUSP00000126273
NCBI entrez gene - 27056     See in Manteia.
MGI - MGI:1350924
RefSeq - XM_006505100
RefSeq - NM_001252382
RefSeq - NM_001311083
RefSeq - NM_012057
RefSeq - XM_006505095
RefSeq - XM_006505097
RefSeq - XM_006505098
RefSeq - XM_006505099
RefSeq Peptide - NP_036187
RefSeq Peptide - NP_001239311
RefSeq Peptide - NP_001298012
swissprot - P56477
swissprot - Q3U169
swissprot - A0A0N4SVY5
swissprot - F6Z6C6
swissprot - E9Q5T2
Ensembl - ENSMUSG00000029771
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf5ENSDARG00000045681Danio rerio
 IRF5ENSGALG00000039982Gallus gallus
 IRF5ENSG00000128604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663849
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135627
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151527
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549823
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318422
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*ENSMUSG0000000232521
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162718
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889914


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR029838  Interferon regulatory factor 5
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032494 response to peptidoglycan IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbfox1tm1.1Dblk/Rbfox1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

Allelic Composition: Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6.129P2-Irf5tm1Ttg

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6.129P2-Irf5tm1Ttg

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

Allelic Composition: Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6.129P2-Irf5tm1Ttg

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6.129P2-Irf5tm1Ttg

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010845 decreased effector memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr