Manteia

ENSMUSG00000026638

Mus musculus

Features

Gene ID:	ENSMUSG00000026638

Biological name :	Irf6

Synonyms :	Interferon regulatory factor 6 / Irf6 / P97431

Possible biological names infered from orthology :	O14896

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H6
Gene start:	193153111
Gene end:	193172023

Corresponding Affymetrix probe sets:	10352815 (MoGene1.0st) 1418301_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000075839 NCBI entrez gene - 54139 See in Manteia. MGI - MGI:1859211 RefSeq - XM_006497263 RefSeq - NM_016851 RefSeq - XM_006497262 RefSeq Peptide - NP_058547 swissprot - P97431 Ensembl - ENSMUSG00000026638

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
irf6	ENSDARG00000101986	Danio rerio
IRF6	ENSGALG00000001405	Gallus gallus
IRF6	ENSG00000117595	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*	ENSMUSG00000029771	52
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*	ENSMUSG00000041515	28
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*	ENSMUSG00000021356	26
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*	ENSMUSG00000025498	24
Irf9 / Q61179 / Interferon regulatory factor 9 / Q00978*	ENSMUSG00000002325	22
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*	ENSMUSG00000003184	21
Irf2 / P23906 / interferon regulatory factor 2 / P14316*	ENSMUSG00000031627	16
Irf1 / P15314 / interferon regulatory factor 1 / P10914*	ENSMUSG00000018899	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR001346	Interferon regulatory factor DNA-binding domain
IPR008984	SMAD/FHA domain superfamily
IPR017855	SMAD-like domain superfamily
IPR019471	Interferon regulatory factor-3
IPR019817	Interferon regulatory factor, conserved site
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007050	cell cycle arrest	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030216	keratinocyte differentiation	IMP
biological_process	GO:0043588	skin development	IMP
biological_process	GO:0043616	keratinocyte proliferation	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048468	cell development	IMP
biological_process	GO:0060644	mammary gland epithelial cell differentiation	IEP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0030054	cell junction	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IDA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000116	abnormal tooth development	"anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000452	abnormal mouth morphology	"anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0000454	abnormal jaw morphology	"malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000467	abnormal esophagus morphology	"malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0000550	abnormal forelimb morphology	"malformation of the entire anterior extremities" [MGI:tc]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0000556	abnormal hindlimb morphology	"malformation of the entire posterior extremities" [MGI:tc]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0000564	syndactyly	"any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0000566	synostosis	"osseous union of two bones that are not normally connected" [J:13049]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0000762	abnormal tongue morphology	"anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0001196	shiny skin	"skin with a glossy or glistening appearance" [J:56641]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001198	tight skin	"skin has a taut, stretched appearance" [J:65038]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001231	abnormal basal cell layer morphology	"structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0001233	abnormal suprabasal layer morphology	"malformed or atypical condition of the suprabasal layer of the skin" [J:56777]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001236	abnormal spinous layer morphology	"structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001241	absent cornified layer	"missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0001284	absent vibrissae	"missing whiskers" [J:18378]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0002655	abnormal keratinocyte morphology	"structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0002656	abnormal keratinocyte differentiation	"developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0003160	abnormal esophageal development	"aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003385	abnormal body wall	"malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Grhl3^tm1Bogi/Grhl3⁺,Irf6^{Gt(OST398253)Lex}/Irf6⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J
MP:0003941	abnormal skin development	"anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB Allelic Composition: Irf6^tm1.1Bcsl/Irf6^tm1.1Bcsl Genetic Background: Not Specified
MP:0004321	short sternum	"reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0004449	absent presphenoid bone	"absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0004537	abnormal palatine shelf	"any structural anomaly of the palatine bone; normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0004592	small mandible	"reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0004596	abnormal mandibular angle morphology	"any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0004610	small vertebrae	"reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0004678	split xiphoid process	"the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0005306	abnormal phalanx morphology	"aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0005358	abnormal incisor morphology	"structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Chuk^tm1Mka/Chuk^tm1Mka,Irf6^tm1Mjd/Irf6⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Chuk^tm1Mka/Chuk⁺,Irf6^tm1Mjd/Irf6^tm1Mjd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0005579	absent outer ear	"missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0006280	abnormal digit development	"anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0008730	fused phalanges	"anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0009441	delayed skin barrier formation	"slowed progression in the establishment of the ability of the skin to regulate water loss" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0009474	thick epidermal spinous layer	"increased thickness of the stratum spinosum; the polyhedral cell layer" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009560	absent epidermis stratum granulosum	"absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^tm1Mjd/Irf6⁺,Sfn^Er/Sfn⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009583	increased keratinocyte proliferation	"increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009653	abnormal palate development	"abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0009884	palatal shelf fusion with tongue or mandible	"palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Irf6^tm1Mjd/Irf6^tm1Mjd Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009886	failure of palatal shelf elevation	"the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Irf6^tm1Mjd/Irf6^tm1Mjd Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Irf6^clft1/Irf6^clft1 Genetic Background: involves: A/J * FVB
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Grhl3^tm1Bogi/Grhl3⁺,Irf6^{Gt(OST398253)Lex}/Irf6⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt Genetic Background: involves: BALB/c * C3H/HeN
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Grhl3^tm1Bogi/Grhl3⁺,Irf6^{Gt(OST398253)Lex}/Irf6⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J
MP:0013531	abnormal periderm development	"abnormal formation of the outermost layer of the bilaminar embryonic/fetal epidermis; periderm cells emerge at approximately E9.5 and form simple squamous epithelium, the most superficial embryonic layer; these cells form the first, but temporary, embryonic permeability barrier, and are replaced by the cornified envelope, that forms during keratinocyte stratification, by E16.5" [http://discovery.lifemapsc.com/in-vivo-development/epidermis/embryonic-epidermis/periderm-cells, MGI:Anna]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Grhl3^tm1Bogi/Grhl3⁺,Irf6^{Gt(OST398253)Lex}/Irf6⁺ Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J
MP:0013818	abnormal oral cavity morphology	"any structural anomaly of the anatomical cavity at the start of the digestive tract that is enclosed by the mouth" [UBERON:0000167]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0030188	round snout	"appearance of the anterior facial part of the face or muzzle containing the oral and nasal regions is more circular than usual" [MGI:anna]	Show Allelic Composition: Irf6^{Gt(OST398253)Lex}/Irf6^{Gt(OST398253)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr