ENSMUSG00000002325


Mus musculus

Features
Gene ID: ENSMUSG00000002325
  
Biological name :Irf9
  
Synonyms : Interferon regulatory factor 9 / Irf9 / Q61179
  
Possible biological names infered from orthology : Q00978
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55603571
Gene end: 55610030
  
Corresponding Affymetrix probe sets: 10415319 (MoGene1.0st)   1421322_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154635
Ensembl peptide - ENSMUSP00000119477
Ensembl peptide - ENSMUSP00000120359
Ensembl peptide - ENSMUSP00000120525
NCBI entrez gene - 16391     See in Manteia.
MGI - MGI:107587
RefSeq - NM_001159417
RefSeq - NM_001159418
RefSeq - NM_008394
RefSeq Peptide - NP_001152890
RefSeq Peptide - NP_001152889
RefSeq Peptide - NP_032420
swissprot - Q3UKQ7
swissprot - E9PZJ2
swissprot - Q61179
swissprot - E9Q8M6
Ensembl - ENSMUSG00000002325
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf9ENSDARG00000016457Danio rerio
 IRF9ENSG00000213928Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irf4 / Q64287 / interferon regulatory factor 4 / Q15306*ENSMUSG0000002135628
Irf8 / P23611 / interferon regulatory factor 8 / Q02556*ENSMUSG0000004151528
Irf6 / P97431 / Interferon regulatory factor 6 / O14896*ENSMUSG0000002663822
Irf5 / P56477 / Interferon regulatory factor 5 / Q13568*ENSMUSG0000002977122
Irf7 / P70434 / interferon regulatory factor 7 / Q92985*ENSMUSG0000002549818
Irf3 / P70671 / interferon regulatory factor 3 / Q14653*ENSMUSG0000000318415
Irf2 / P23906 / interferon regulatory factor 2 / P14316*ENSMUSG0000003162712
Irf1 / P15314 / interferon regulatory factor 1 / P10914*ENSMUSG0000001889912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001346  Interferon regulatory factor DNA-binding domain
 IPR008984  SMAD/FHA domain superfamily
 IPR017855  SMAD-like domain superfamily
 IPR019471  Interferon regulatory factor-3
 IPR019817  Interferon regulatory factor, conserved site
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045351 type I interferon biosynthetic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf2tm1Mak/Irf2tm1Mak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Actc1tm1Jll/Actc1tm1Jll,Tg(Myh6-Actg2)1Jll/0
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfdtm1Mach/Y
Genetic Background: involves: 129S1/Sv

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0008575 increased circulating interferon-beta level "increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Itkm1Btlr/Itkm1Btlr
Genetic Background: C57BL/6J-Itkm1Btlr

Allelic Composition: Irf9M1Btlr/Irf9+
Genetic Background: C57BL/6J-Irf9M1Btlr

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Itkm1Btlr/Itkm1Btlr
Genetic Background: C57BL/6J-Itkm1Btlr

Allelic Composition: Irf9M1Btlr/Irf9+
Genetic Background: C57BL/6J-Irf9M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex / reaction






 

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