ENSDARG00000102493


Danio rerio

Features
Gene ID: ENSDARG00000102493
  
Biological name :ticam1
  
Synonyms : ticam1 / toll-like receptor adaptor molecule 1
  
Possible biological names infered from orthology : Q80UF7 / Q86XR7 / Q8BJQ4 / Q8IUC6 / TICAM2 / TIR domain-containing adapter molecule 1 / TIR domain-containing adapter molecule 2 / toll like receptor adaptor molecule 2
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 4442473
Gene end: 4445833
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130000
Ensembl peptide - ENSDARP00000150114
NCBI entrez gene - 403147     See in Manteia.
RefSeq - NM_001044759
RefSeq Peptide - NP_001038224
swissprot - Q1LUQ2
ZFIN ID - ZDB-GENE-040219-2
Ensembl - ENSDARG00000102493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TICAM1ENSGALG00000026850Gallus gallus
 Q86XR7ENSG00000243414Homo sapiens
 Q8IUC6ENSG00000127666Homo sapiens
 Q80UF7ENSMUSG00000047123Mus musculus
 Q8BJQ4ENSMUSG00000056130Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Neutrophil degranulation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex
 ENSDARG00000045661 irf7 / interferon regulatory factor 7 / P70434* / Q92985*  / reaction / complex
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / reaction / complex
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex
 ENSDARG00000062063 tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex






 

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