ENSDARG00000021509


Danio rerio

Features
Gene ID: ENSDARG00000021509
  
Biological name :tab2
  
Synonyms : Q5RFW2 / tab2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2
  
Possible biological names infered from orthology : Q99K90 / Q9NYJ8 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 1329509
Gene end: 1350296
  
Corresponding Affymetrix probe sets: Dr.10125.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000019647
Ensembl peptide - ENSDARP00000117382
Ensembl peptide - ENSDARP00000151152
NCBI entrez gene - 494163     See in Manteia.
RefSeq - NM_001316693
RefSeq Peptide - NP_001303622
swissprot - Q5RFW2
swissprot - T1ECV1
ZFIN ID - ZDB-GENE-040426-933
Ensembl - ENSDARG00000021509
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TAB2ENSGALG00000012356Gallus gallus
 TAB2ENSG00000055208Homo sapiens
 Tab2ENSMUSG00000015755Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*ENSDARG0000006206330


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR003892  Ubiquitin system component Cue


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart decreased functionality , abnormal
heart decreased thickness , abnormal
heart elongated , abnormal
Show

 ZFA:0001655 pericardial cavity pericardial cavity increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex
 ENSDARG00000062063 tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex
 ENSDARG00000077768 malt1 / MALT paracaspase 1 / Q2TBA3* / Q9UDY8* / MALT1 paracaspase* / Mucosa-associated lymphoid tissue lymphoma translocation *  / reaction / complex
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / complex / reaction
 ENSDARG00000077130 bcl10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / reaction / complex
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000034173 prkcq / protein kinase C, theta / Q02111* / Q04759*  / reaction / complex
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex
 ENSDARG00000067672 card9 / caspase recruitment domain family, member 9 / Q9H257*  / reaction / complex
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex / reaction
 ENSDARG00000010756 nod2 / nucleotide-binding oligomerization domain containing 2 / Q8K3Z0* / Q9HC29* / Nucleotide-binding oligomerization domain-containing protein 2 *  / reaction / complex
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex






 

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