ENSGALG00000009840


Gallus gallus

Features
Gene ID: ENSGALG00000009840
  
Biological name :TBK1
  
Synonyms : TANK binding kinase 1 / TBK1
  
Possible biological names infered from orthology : Q9UHD2 / Q9WUN2
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 33641818
Gene end: 33664801
  
Corresponding Affymetrix probe sets: Gga.10010.1.S1_at (Chicken Array)   GgaAffx.6169.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015982
NCBI entrez gene - 417825     See in Manteia.
RefSeq - XM_015281572
RefSeq - NM_001199558
RefSeq - XM_015281560
RefSeq - XM_015281567
RefSeq - XM_015281552
RefSeq Peptide - NP_001186487
swissprot - E1C581
Ensembl - ENSGALG00000009840
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbk1ENSDARG00000103095Danio rerio
 TBK1ENSG00000183735Homo sapiens
 Tbk1ENSMUSG00000020115Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IKBKE / inhibitor of nuclear factor kappa B kinase subunit epsilon / Q14164* / Q9R0T8*ENSGALG0000001335643
CHUK / inhibitor of nuclear factor kappa-B kinase subunit alpha / O15111* / conserved helix-loop-helix ubiquitous kinase*ENSGALG0000000328920
ULK1 / unc-51 like autophagy activating kinase 1 / O75385* / unc-51 like kinase 1*ENSGALG0000000240317
ULK2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSGALG0000000472716
IKBKB / inhibitor of nuclear factor kappa B kinase subunit beta / O14920* / inhibitor of kappaB kinase beta*ENSGALG0000003183213
ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*ENSGALG0000003221512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044565 dendritic cell proliferation IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:1904417 positive regulation of xenophagy IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016235 aggresome IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
STAT6-mediated induction of chemokines
Interleukin-37 signaling
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011389 TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*  / reaction / complex
 ENSGALG00000011131 TANK / TRAF family member associated NFKB activator / P70347* / Q92844* / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA.*  / reaction / complex
 ENSGALG00000009840 TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*  / complex / reaction
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction
 ENSGALG00000041129 TMEM173 / stimulator of interferon genes protein / Q86WV6* / Q3TBT3* / transmembrane protein 173* / Stimulator of interferons protein *  / complex / reaction
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSGALG00000013861 TNFAIP3 / TNF alpha induced protein 3 / P21580* / Q60769* / tumor necrosis factor, alpha-induced protein 3*  / complex / reaction
 ENSGALG00000042822 TAX1BP1 / Tax1 binding protein 1 / Q3UKC1* / Q86VP1* / Tax1-binding *  / reaction / complex






 

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