ENSGALG00000013861


Gallus gallus

Features
Gene ID: ENSGALG00000013861
  
Biological name :TNFAIP3
  
Synonyms : TNFAIP3 / TNF alpha induced protein 3
  
Possible biological names infered from orthology : P21580 / Q60769 / tumor necrosis factor, alpha-induced protein 3
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 54742403
Gene end: 54761225
  
Corresponding Affymetrix probe sets: Gga.1025.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000022443
Ensembl peptide - ENSGALP00000046998
NCBI entrez gene - 421684     See in Manteia.
RefSeq - XM_015284187
RefSeq - XM_015284186
swissprot - E1BZ59
swissprot - A0A1D5P2U8
Ensembl - ENSGALG00000013861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaip3ENSDARG00000027777Danio rerio
 P21580ENSG00000118503Homo sapiens
 Q60769ENSMUSG00000019850Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTUD7A / OTU deubiquitinase 7A / Q8R554* / Q8TE49* / OTU domain-containing protein 7A *ENSGALG0000000380222
OTUD7B / OTU deubiquitinase 7B / B2RUR8* / Q6GQQ9* / OTU domain-containing protein 7B *ENSGALG0000001334821
ZRANB1 / zinc finger RANBP2-type containing 1 / Q7M760* / Q9UGI0* / zinc finger, RAN-binding domain containing 1*ENSGALG0000003147414


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain
 IPR033478  A20 peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001922 B-1 B cell homeostasis IEA
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002634 regulation of germinal center formation IEA
 biological_processGO:0002677 negative regulation of chronic inflammatory response IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034140 negative regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034148 negative regulation of toll-like receptor 5 signaling pathway IEA
 biological_processGO:0035871 protein K11-linked deubiquitination IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045088 regulation of innate immune response IBA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050869 negative regulation of B cell activation IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070429 negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0072573 tolerance induction to lipopolysaccharide IEA
 biological_processGO:0072666 establishment of protein localization to vacuole IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 biological_processGO:2000349 negative regulation of CD40 signaling pathway IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000009840 TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*  / reaction / complex
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / complex
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction / complex
 ENSGALG00000042822 TAX1BP1 / Tax1 binding protein 1 / Q3UKC1* / Q86VP1* / Tax1-binding *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr