ENSGALG00000013356


Gallus gallus

Features
Gene ID: ENSGALG00000013356
  
Biological name :IKBKE
  
Synonyms : IKBKE / inhibitor of nuclear factor kappa B kinase subunit epsilon
  
Possible biological names infered from orthology : Q14164 / Q9R0T8
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 2475901
Gene end: 2484810
  
Corresponding Affymetrix probe sets: GgaAffx.8507.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000021757
NCBI entrez gene - 430480     See in Manteia.
RefSeq - XM_015299067
RefSeq - XM_015299068
RefSeq - XM_015299069
RefSeq - XM_428036
RefSeq - XM_015299066
swissprot - E1BV51
Ensembl - ENSGALG00000013356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ikbkeENSDARG00000070606Danio rerio
 IKBKEENSG00000263528Homo sapiens
 IkbkeENSMUSG00000042349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*ENSGALG0000000984046
CHUK / inhibitor of nuclear factor kappa-B kinase subunit alpha / O15111* / conserved helix-loop-helix ubiquitous kinase*ENSGALG0000000328920
ULK1 / unc-51 like autophagy activating kinase 1 / O75385* / unc-51 like kinase 1*ENSGALG0000000240318
ULK2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSGALG0000000472718
IKBKB / inhibitor of nuclear factor kappa B kinase subunit beta / O14920* / inhibitor of kappaB kinase beta*ENSGALG0000003183214
ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*ENSGALG0000003221511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0034340 response to type I interferon IEA
 biological_processGO:0035456 response to interferon-beta IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0098586 cellular response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036435 K48-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of immune response proteins
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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