ENSGALG00000031832


Gallus gallus

Features
Gene ID: ENSGALG00000031832
  
Biological name :IKBKB
  
Synonyms : IKBKB / inhibitor of nuclear factor kappa B kinase subunit beta
  
Possible biological names infered from orthology : inhibitor of kappaB kinase beta / O14920
  
Species: Gallus gallus
  
Chr. number: 22
Strand: 1
Band:
Gene start: 2750637
Gene end: 2762679
  
Corresponding Affymetrix probe sets: GgaAffx.13004.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046104
Ensembl peptide - ENSGALP00000052451
Ensembl peptide - ENSGALP00000051668
NCBI entrez gene - 107054958     See in Manteia.
RefSeq - XM_015297378
RefSeq - XM_015297379
RefSeq - XM_015297380
swissprot - A0A1D5PI19
swissprot - A0A1D5PFV1
swissprot - A0A1D5P0C9
Ensembl - ENSGALG00000031832
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ikbkbENSDARG00000079123Danio rerio
 IKBKBENSG00000104365Homo sapiens
 IkbkbENSMUSG00000031537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHUK / inhibitor of nuclear factor kappa-B kinase subunit alpha / O15111* / conserved helix-loop-helix ubiquitous kinase*ENSGALG0000000328940
ULK2 / unc-51 like autophagy activating kinase 2 / Q8IYT8* / Q9QY01* / unc-51 like kinase 2*ENSGALG0000000472715
ULK1 / unc-51 like autophagy activating kinase 1 / O75385* / unc-51 like kinase 1*ENSGALG0000000240315
TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*ENSGALG0000000984014
IKBKE / inhibitor of nuclear factor kappa B kinase subunit epsilon / Q14164* / Q9R0T8*ENSGALG0000001335613
ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*ENSGALG000000322159


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR022007  I-kappa-kinase-beta NEMO binding domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008384 IkappaB kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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