ENSDARG00000091058


Danio rerio

Features
Gene ID: ENSDARG00000091058
  
Biological name :tmem173
  
Synonyms : tmem173 / transmembrane protein 173
  
Possible biological names infered from orthology : Q3TBT3 / Q86WV6 / Stimulator of interferons protein
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 7764331
Gene end: 7786585
  
Corresponding Affymetrix probe sets: Dr.22308.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105858
Ensembl peptide - ENSDARP00000148153
NCBI entrez gene - 101243556     See in Manteia.
RefSeq - XM_005157121
swissprot - E7F4N7
ZFIN ID - ZDB-GENE-120921-1
Ensembl - ENSDARG00000091058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TMEM173ENSGALG00000041129Gallus gallus
 Q86WV6ENSG00000184584Homo sapiens
 Q3TBT3ENSMUSG00000024349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029158  Stimulator of interferon genes protein
 IPR033952  Stimulator of interferon genes protein, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IDA
 biological_processGO:0010506 regulation of autophagy IGI
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0032606 type I interferon production IDA
 biological_processGO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0035438 cyclic-di-GMP binding IEA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000110 fourth ventricle fourth ventricle monocyte decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism amount , ameliorated
whole organism decreased life span , exacerbated
whole organism decreased pigmentation , abnormal
Show

 ZFA:0001115 trunk trunk shortened , abnormal
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 ZFA:0009000 cell cell autophagosome decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex
 ENSDARG00000015902 stat6 / signal transducer and activator of transcription 6, interleukin-4 induced / P42226* / P52633* / Signal transducer and transcription activator 6 * / signal transducer and activator o...  / complex / reaction
 ENSDARG00000076302 DTX4 / si:ch211-119e14.2 / Q6PDK8* / Q9Y2E6* / deltex E3 ubiquitin ligase 4* / E3 ubiquitin-protein ligase DTX4 *  / reaction / complex
 ENSDARG00000103095 tbk1 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSDARG00000078016 dtx4 / deltex 4, E3 ubiquitin ligase / Q9Y2E6* / Q6PDK8* / deltex E3 ubiquitin ligase 4* / E3 ubiquitin-protein ligase DTX4 *  / reaction / complex
 ENSDARG00000091058 tmem173 / transmembrane protein 173 / Q3TBT3* / Q86WV6* / Stimulator of interferons protein *  / reaction / complex






 

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