ENSMUSG00000024349


Mus musculus

Features
Gene ID: ENSMUSG00000024349
  
Biological name :Tmem173
  
Synonyms : Q3TBT3 / Stimulator of interferons protein / Tmem173
  
Possible biological names infered from orthology : Q86WV6 / transmembrane protein 173
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 35733678
Gene end: 35740554
  
Corresponding Affymetrix probe sets: 10458314 (MoGene1.0st)   1427911_at (Mouse Genome 430 2.0 Array)   1447621_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111393
NCBI entrez gene - 72512     See in Manteia.
MGI - MGI:1919762
RefSeq - NM_028261
RefSeq - XM_017317994
RefSeq - NM_001289591
RefSeq - NM_001289592
RefSeq Peptide - NP_001276521
RefSeq Peptide - NP_082537
RefSeq Peptide - NP_001276520
swissprot - Q3TBT3
Ensembl - ENSMUSG00000024349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem173ENSDARG00000091058Danio rerio
 TMEM173ENSGALG00000041129Gallus gallus
 Q86WV6ENSG00000184584Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029158  Stimulator of interferon genes protein
 IPR033952  Stimulator of interferon genes protein, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032481 positive regulation of type I interferon production IDA
 biological_processGO:0032608 interferon-beta production IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0035458 cellular response to interferon-beta IMP
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035438 cyclic-di-GMP binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0061507 cyclic-GMP-AMP binding IDA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Irf8myls/Irf8+
Genetic Background: involves: BXH2/TyJ * C57BL/6

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf8myls/Irf8+
Genetic Background: involves: BXH2/TyJ * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trpm4tm1.1Knt/Trpm4tm1.1Knt,Trpm5tm1Csz/Trpm5tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Trpm4tm1.1Knt/Trpm4tm1.1Knt,Trpm5tm1Csz/Trpm5tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tmem173tm1Camb/Tmem173tm1Camb
Genetic Background: involves: C57BL/6N

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem173gt/Tmem173gt
Genetic Background: C57BL/6-Tmem173gt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000039982 Dtx4 / Q6PDK8 / E3 ubiquitin-protein ligase DTX4 / Q9Y2E6* / deltex E3 ubiquitin ligase 4*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / complex / reaction
 ENSMUSG00000043279 Trim56 / tripartite motif containing 56 / Q9BRZ2*  / reaction / complex
 ENSMUSG00000024349 Q3TBT3 / Tmem173 / Stimulator of interferons protein / Q86WV6* / transmembrane protein 173*  / reaction / complex
 ENSMUSG00000051675 Q8CH72 / Trim32 / tripartite motif-containing 32 / Q13049*  / reaction / complex






 

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