ENSMUSG00000051675


Mus musculus

Features
Gene ID: ENSMUSG00000051675
  
Biological name :Trim32
  
Synonyms : Q8CH72 / Trim32 / tripartite motif-containing 32
  
Possible biological names infered from orthology : Q13049
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C1
Gene start: 65604986
Gene end: 65616238
  
Corresponding Affymetrix probe sets: 10505512 (MoGene1.0st)   1427476_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121949
Ensembl peptide - ENSMUSP00000062277
Ensembl peptide - ENSMUSP00000102989
Ensembl peptide - ENSMUSP00000119579
NCBI entrez gene - 69807     See in Manteia.
MGI - MGI:1917057
RefSeq - XM_006538238
RefSeq - NM_001161782
RefSeq - NM_053084
RefSeq - XM_006538235
RefSeq - XM_006538236
RefSeq - XM_006538237
RefSeq Peptide - NP_001155254
RefSeq Peptide - NP_444314
swissprot - Q3TLR3
swissprot - A2AGS1
swissprot - Q8CH72
swissprot - A2AGS0
Ensembl - ENSMUSG00000051675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRIM32ENSGALG00000034426Gallus gallus
 Q13049ENSG00000119401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nhlrc4 / Q3UP44 / NHL-repeat-containing protein 4 / P0CG21* / NHL repeat containing 4*ENSMUSG000000901138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001258  NHL repeat
 IPR001841  Zinc finger, RING-type
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013017  NHL repeat, subgroup
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0007014 actin ubiquitination IDA
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030307 positive regulation of cell growth ISS
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0032897 negative regulation of viral transcription ISO
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045444 fat cell differentiation IEP
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0045787 positive regulation of cell cycle ISS
 biological_processGO:0045862 positive regulation of proteolysis ISS
 biological_processGO:0046716 muscle cell cellular homeostasis IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEP
 biological_processGO:0050769 positive regulation of neurogenesis IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation IMP
 biological_processGO:0061564 axon development IMP
 biological_processGO:1902173 negative regulation of keratinocyte apoptotic process NAS
 biological_processGO:1902187 negative regulation of viral release from host cell ISO
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISS
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:1903883 positive regulation of interleukin-17-mediated signaling pathway IMP
 biological_processGO:1903886 positive regulation of chemokine (C-C motif) ligand 20 production IMP
 biological_processGO:2000147 positive regulation of cell motility IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005863 striated muscle myosin thick filament IDA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017022 myosin binding IPI
 molecular_functionGO:0031369 translation initiation factor binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0043621 protein self-association ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
Regulation of innate immune responses to cytosolic DNA
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000730 increased number of satellite cells "greater number of unfused cells in muscle that play a role in muscle regeneration" [J:42574]
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Hoxa1tm8.2Mrc/Hoxa1tm8.2Mrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Trim32tm1Hdin/Trim32tm1Hdin
Genetic Background: involves: 129S1/Sv

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Hoxa1tm8.2Mrc/Hoxa1tm8.2Mrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Trim32tm1Spc/Trim32tm1Spc
Genetic Background: involves: 129S/SvEvBrd * BALB/cJ * C57BL/6J

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim32tm1Hdin/Trim32tm1Hdin
Genetic Background: involves: 129S1/Sv

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Trim32tm1Spc/Trim32tm1Spc
Genetic Background: involves: 129S/SvEvBrd * BALB/cJ * C57BL/6J

Allelic Composition: Trim32tm1Hdin/Trim32tm1Hdin
Genetic Background: involves: 129S1/Sv

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/?
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Allelic Composition: Trim32tm1Spc/Trim32tm1Spc
Genetic Background: involves: 129S/SvEvBrd * BALB/cJ * C57BL/6J

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Trim32tm1Hdin/Trim32tm1Hdin
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024349 Q3TBT3 / Tmem173 / Stimulator of interferons protein / Q86WV6* / transmembrane protein 173*  / reaction / complex






 

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