ENSMUSG00000039982


Mus musculus

Features
Gene ID: ENSMUSG00000039982
  
Biological name :Dtx4
  
Synonyms : Dtx4 / E3 ubiquitin-protein ligase DTX4 / Q6PDK8
  
Possible biological names infered from orthology : deltex E3 ubiquitin ligase 4 / Q9Y2E6
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 12466341
Gene end: 12501996
  
Corresponding Affymetrix probe sets: 10466304 (MoGene1.0st)   1436545_at (Mouse Genome 430 2.0 Array)   1455711_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040229
NCBI entrez gene - 207521     See in Manteia.
MGI - MGI:2672905
RefSeq - NM_172442
RefSeq - XM_006526816
RefSeq Peptide - NP_766030
swissprot - Q6PDK8
Ensembl - ENSMUSG00000039982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtx4ENSDARG00000078016Danio rerio
 DTX4ENSDARG00000076302Danio rerio
 DTX4ENSGALG00000010835Gallus gallus
 DTX4ENSG00000110042Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dtx1 / Q61010 / E3 ubiquitin-protein ligase DTX1 / Q86Y01* / deltex E3 ubiquitin ligase 1*ENSMUSG0000002960362
Dtx2 / Q8R3P2 / Probable E3 ubiquitin-protein ligase DTX2 / Q86UW9* / deltex E3 ubiquitin ligase 2*ENSMUSG0000000494744
Dtx3l / Q3UIR3 / E3 ubiquitin-protein ligase DTX3L / Q8TDB6* / deltex E3 ubiquitin ligase 3L*ENSMUSG0000004950220
Dtx3 / Q80V91 / Probable E3 ubiquitin-protein ligase DTX3 / Q8N9I9* / deltex E3 ubiquitin ligase 3*ENSMUSG0000004041515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018123  WWE domain, subgroup
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000024349 Q3TBT3 / Tmem173 / Stimulator of interferons protein / Q86WV6* / transmembrane protein 173*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction






 

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