ENSMUSG00000029603


Mus musculus

Features
Gene ID: ENSMUSG00000029603
  
Biological name :Dtx1
  
Synonyms : Dtx1 / E3 ubiquitin-protein ligase DTX1 / Q61010
  
Possible biological names infered from orthology : deltex E3 ubiquitin ligase 1 / Q86Y01
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 120680202
Gene end: 120711927
  
Corresponding Affymetrix probe sets: 10533182 (MoGene1.0st)   1425822_a_at (Mouse Genome 430 2.0 Array)   1458643_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031607
NCBI entrez gene - 14357     See in Manteia.
MGI - MGI:1352744
RefSeq - XM_011248181
RefSeq - NM_008052
RefSeq - XM_011248180
RefSeq Peptide - NP_032078
swissprot - Q61010
Ensembl - ENSMUSG00000029603
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DTX1ENSGALG00000027897Gallus gallus
 DTX1ENSG00000135144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dtx4 / Q6PDK8 / E3 ubiquitin-protein ligase DTX4 / Q9Y2E6* / deltex E3 ubiquitin ligase 4*ENSMUSG0000003998260
Dtx2 / Q8R3P2 / Probable E3 ubiquitin-protein ligase DTX2 / Q86UW9* / deltex E3 ubiquitin ligase 2*ENSMUSG0000000494746
Dtx3l / Q3UIR3 / E3 ubiquitin-protein ligase DTX3L / Q8TDB6* / deltex E3 ubiquitin ligase 3L*ENSMUSG0000004950221
Dtx3 / Q80V91 / Probable E3 ubiquitin-protein ligase DTX3 / Q8N9I9* / deltex E3 ubiquitin ligase 3*ENSMUSG0000004041515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018123  WWE domain, subgroup
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0008593 regulation of Notch signaling pathway IEA
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045581 negative regulation of T cell differentiation IDA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Dtx1tm1.1Mzl/Dtx1tm1.1Mzl,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dtx1tm1.1Mzl/Dtx1tm1.1Mzl,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dtx1tm1.1Mzl/Dtx1tm1.1Mzl,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dtx1tm1.1Mzl/Dtx1tm1.1Mzl,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dtx1tm1.1Mzl/Dtx1tm1.1Mzl,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Dtx1tm1.1Mzl/Dtx1tm1.1Mzl,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008747 abnormal T cell anergy "any anomaly in the process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction" [GO:0002870]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / reaction / complex
 ENSMUSG00000036766 Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*  / complex / reaction
 ENSMUSG00000027598 Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*  / reaction / complex






 

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