ENSG00000135144


Homo sapiens

Features
Gene ID: ENSG00000135144
  
Biological name :DTX1
  
Synonyms : deltex E3 ubiquitin ligase 1 / DTX1 / Q86Y01
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.13
Gene start: 113056709
Gene end: 113098028
  
Corresponding Affymetrix probe sets: 227336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257600
NCBI entrez gene - 1840     See in Manteia.
OMIM - 602582
RefSeq - NM_004416
RefSeq - XM_011538009
RefSeq Peptide - NP_004407
swissprot - Q86Y01
Ensembl - ENSG00000135144
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DTX1ENSGALG00000027897Gallus gallus
 Dtx1ENSMUSG00000029603Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DTX4 / Q9Y2E6 / deltex E3 ubiquitin ligase 4ENSG0000011004263
DTX2 / Q86UW9 / deltex E3 ubiquitin ligase 2ENSG0000009107347
DTX3L / Q8TDB6 / deltex E3 ubiquitin ligase 3LENSG0000016384023
DTX3 / Q8N9I9 / deltex E3 ubiquitin ligase 3ENSG0000017849814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018123  WWE domain, subgroup
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated NAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0008593 regulation of Notch signaling pathway IGI
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045581 negative regulation of T cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IGI
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005112 Notch binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / complex / reaction
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex
 ENSG00000078747 ITCH / Q96J02 / itchy E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000187957 DNER / Q8NFT8 / delta/notch like EGF repeat containing  / reaction / complex
 ENSG00000018236 CNTN1 / Q12860 / contactin 1  / complex / reaction






 

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