ENSG00000110042


Homo sapiens

Features
Gene ID: ENSG00000110042
  
Biological name :DTX4
  
Synonyms : deltex E3 ubiquitin ligase 4 / DTX4 / Q9Y2E6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.1
Gene start: 59171430
Gene end: 59208587
  
Corresponding Affymetrix probe sets: 212611_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227451
Ensembl peptide - ENSP00000434055
NCBI entrez gene - 23220     See in Manteia.
OMIM - 616110
RefSeq - XM_006718483
RefSeq - NM_001300727
RefSeq - NM_015177
RefSeq Peptide - NP_055992
RefSeq Peptide - NP_001287656
swissprot - Q9Y2E6
Ensembl - ENSG00000110042
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtx4ENSDARG00000078016Danio rerio
 DTX4ENSDARG00000076302Danio rerio
 DTX4ENSGALG00000010835Gallus gallus
 Dtx4ENSMUSG00000039982Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DTX1 / Q86Y01 / deltex E3 ubiquitin ligase 1ENSG0000013514463
DTX2 / Q86UW9 / deltex E3 ubiquitin ligase 2ENSG0000009107345
DTX3L / Q8TDB6 / deltex E3 ubiquitin ligase 3LENSG0000016384022
DTX3 / Q8N9I9 / deltex E3 ubiquitin ligase 3ENSG0000017849815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR004170  WWE domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018123  WWE domain, subgroup
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032479 regulation of type I interferon production TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
IRF3 mediated activation of type 1 IFN
Activated NOTCH1 Transmits Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160505 NLRP4 / Q96MN2 / NLR family pyrin domain containing 4  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / reaction / complex
 ENSG00000184584 Q86WV6 / TMEM173 / transmembrane protein 173  / complex / reaction
 ENSG00000124256 ZBP1 / Q9H171 / Z-DNA binding protein 1  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr