ENSG00000163840


Homo sapiens

Features
Gene ID: ENSG00000163840
  
Biological name :DTX3L
  
Synonyms : deltex E3 ubiquitin ligase 3L / DTX3L / Q8TDB6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q21.1
Gene start: 122564238
Gene end: 122575203
  
Corresponding Affymetrix probe sets: 225415_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373157
Ensembl peptide - ENSP00000296161
NCBI entrez gene - 151636     See in Manteia.
OMIM - 613143
RefSeq - NM_138287
RefSeq Peptide - NP_612144
swissprot - Q8TDB6
Ensembl - ENSG00000163840
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DTX3LENSGALG00000012075Gallus gallus
 Dtx3lENSMUSG00000049502Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DTX2 / Q86UW9 / deltex E3 ubiquitin ligase 2ENSG0000009107319
DTX1 / Q86Y01 / deltex E3 ubiquitin ligase 1ENSG0000013514419
DTX3 / Q8N9I9 / deltex E3 ubiquitin ligase 3ENSG0000017849818
DTX4 / Q9Y2E6 / deltex E3 ubiquitin ligase 4ENSG0000011004218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002230 positive regulation of defense response to virus by host IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0008333 endosome to lysosome transport IMP
 biological_processGO:0010390 histone monoubiquitination IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0033522 histone H2A ubiquitination IMP
 biological_processGO:0033523 histone H2B ubiquitination IMP
 biological_processGO:0035563 positive regulation of chromatin binding IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IMP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051865 protein autoubiquitination IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IGI
 biological_processGO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity IDA
 biological_processGO:1902966 positive regulation of protein localization to early endosome IMP
 biological_processGO:2000646 positive regulation of receptor catabolic process IMP
 biological_processGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0004857 enzyme inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097677 STAT family protein binding IPI


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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