ENSMUSG00000049502


Mus musculus

Features
Gene ID: ENSMUSG00000049502
  
Biological name :Dtx3l
  
Synonyms : Dtx3l / E3 ubiquitin-protein ligase DTX3L / Q3UIR3
  
Possible biological names infered from orthology : deltex E3 ubiquitin ligase 3L / Q8TDB6
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 35926511
Gene end: 35939151
  
Corresponding Affymetrix probe sets: 10439268 (MoGene1.0st)   1435208_at (Mouse Genome 430 2.0 Array)   1439825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080601
Ensembl peptide - ENSMUSP00000110535
NCBI entrez gene - 209200     See in Manteia.
MGI - MGI:2656973
RefSeq - NM_001013371
RefSeq Peptide - NP_001013389
swissprot - Q3UIR3
Ensembl - ENSMUSG00000049502
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DTX3LENSGALG00000012075Gallus gallus
 DTX3LENSG00000163840Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dtx3 / Q80V91 / Probable E3 ubiquitin-protein ligase DTX3 / Q8N9I9* / deltex E3 ubiquitin ligase 3*ENSMUSG0000004041519
Dtx2 / Q8R3P2 / Probable E3 ubiquitin-protein ligase DTX2 / Q86UW9* / deltex E3 ubiquitin ligase 2*ENSMUSG0000000494718
Dtx1 / Q61010 / E3 ubiquitin-protein ligase DTX1 / Q86Y01* / deltex E3 ubiquitin ligase 1*ENSMUSG0000002960317
Dtx4 / Q6PDK8 / E3 ubiquitin-protein ligase DTX4 / Q9Y2E6* / deltex E3 ubiquitin ligase 4*ENSMUSG0000003998217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0008333 endosome to lysosome transport ISO
 biological_processGO:0010390 histone monoubiquitination ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0033522 histone H2A ubiquitination ISO
 biological_processGO:0033523 histone H2B ubiquitination ISO
 biological_processGO:0035563 positive regulation of chromatin binding ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity ISO
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0070936 protein K48-linked ubiquitination ISO
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 biological_processGO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity ISO
 biological_processGO:1902966 positive regulation of protein localization to early endosome ISO
 biological_processGO:2000646 positive regulation of receptor catabolic process ISO
 biological_processGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0004857 enzyme inhibitor activity ISO
 molecular_functionGO:0008047 enzyme activator activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097677 STAT family protein binding ISO


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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