Homo sapiens

Gene ID: ENSG00000141480
Biological name :ARRB2
Synonyms : ARRB2 / arrestin beta 2 / P32121
Possible biological names infered from orthology :
Species: Homo sapiens
Chr. number: 17
Strand: 1
Band: p13.2
Gene start: 4710489
Gene end: 4721499
Corresponding Affymetrix probe sets: 203388_at (Human Genome U133 Plus 2.0 Array)   
Cross references: Ensembl peptide - ENSP00000466857
Ensembl peptide - ENSP00000465877
Ensembl peptide - ENSP00000466344
Ensembl peptide - ENSP00000269260
Ensembl peptide - ENSP00000341895
Ensembl peptide - ENSP00000370898
Ensembl peptide - ENSP00000403701
Ensembl peptide - ENSP00000458371
Ensembl peptide - ENSP00000458946
Ensembl peptide - ENSP00000460607
Ensembl peptide - ENSP00000460879
Ensembl peptide - ENSP00000465296
NCBI entrez gene - 409     See in Manteia.
OMIM - 107941
RefSeq - XM_017024645
RefSeq - NM_001257328
RefSeq - NM_001257329
RefSeq - NM_001257330
RefSeq - NM_001257331
RefSeq - NM_004313
RefSeq - NM_199004
RefSeq - XM_006721520
RefSeq - XM_011523858
RefSeq Peptide - NP_001244258
RefSeq Peptide - NP_001244259
RefSeq Peptide - NP_001244260
RefSeq Peptide - NP_001316993
RefSeq Peptide - NP_004304
RefSeq Peptide - NP_945355
RefSeq Peptide - NP_001244257
swissprot - P32121
swissprot - I3L0V6
swissprot - I3L1M6
swissprot - I3L412
swissprot - K7EL17
swissprot - K7ENA6
swissprot - Q68DZ5
Ensembl - ENSG00000141480
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arrb2aENSDARG00000039215Danio rerio
 arrb2bENSDARG00000011545Danio rerio
 Arrb2ENSMUSG00000060216Mus musculus

Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARRB1 / P49407 / arrestin beta 1ENSG0000013748673
SAG / P10523 / S-antigen visual arrestinENSG0000013056150
ARR3 / P36575 / arrestin 3ENSG0000012050050

Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site

Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002031 G-protein coupled receptor internalization TAS
 biological_processGO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway NAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IGI
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IEA
 biological_processGO:0032695 negative regulation of interleukin-12 production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045953 negative regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling NAS
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0060079 excitatory postsynaptic potential NAS
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031691 alpha-1A adrenergic receptor binding IEA
 molecular_functionGO:0031692 alpha-1B adrenergic receptor binding IEA
 molecular_functionGO:0031701 angiotensin receptor binding IPI
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0031762 follicle-stimulating hormone receptor binding IEA
 molecular_functionGO:0031826 type 2A serotonin receptor binding IEA
 molecular_functionGO:0031859 platelet activating factor receptor binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA
 molecular_functionGO:1990763 arrestin family protein binding IEA

Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match

Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000128602 SMO / Q99835 / smoothened, frizzled class receptor  / complex / reaction
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / reaction / complex
 ENSG00000135144 DTX1 / Q86Y01 / deltex E3 ubiquitin ligase 1  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction / complex
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / reaction / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000131437 KIF3A / Q9Y496 / kinesin family member 3A  / reaction / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000181072 CHRM2 / P08172 / cholinergic receptor muscarinic 2  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / complex / reaction
 ENSG00000126895 AVPR2 / P30518 / arginine vasopressin receptor 2  / reaction / complex
 ENSG00000077254 USP33 / Q8TEY7 / ubiquitin specific peptidase 33  / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000101200 AVP / P01185 / arginine vasopressin  / complex / reaction


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