ENSG00000141480


Homo sapiens

Features
Gene ID: ENSG00000141480
  
Biological name :ARRB2
  
Synonyms : ARRB2 / arrestin beta 2 / P32121
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.2
Gene start: 4710489
Gene end: 4721499
  
Corresponding Affymetrix probe sets: 203388_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466857
Ensembl peptide - ENSP00000465877
Ensembl peptide - ENSP00000466344
Ensembl peptide - ENSP00000269260
Ensembl peptide - ENSP00000341895
Ensembl peptide - ENSP00000370898
Ensembl peptide - ENSP00000403701
Ensembl peptide - ENSP00000458371
Ensembl peptide - ENSP00000458946
Ensembl peptide - ENSP00000460607
Ensembl peptide - ENSP00000460879
Ensembl peptide - ENSP00000465296
NCBI entrez gene - 409     See in Manteia.
OMIM - 107941
RefSeq - XM_017024645
RefSeq - NM_001257328
RefSeq - NM_001257329
RefSeq - NM_001257330
RefSeq - NM_001257331
RefSeq - NM_004313
RefSeq - NM_199004
RefSeq - XM_006721520
RefSeq - XM_011523858
RefSeq Peptide - NP_001244258
RefSeq Peptide - NP_001244259
RefSeq Peptide - NP_001244260
RefSeq Peptide - NP_001316993
RefSeq Peptide - NP_004304
RefSeq Peptide - NP_945355
RefSeq Peptide - NP_001244257
swissprot - P32121
swissprot - I3L0V6
swissprot - I3L1M6
swissprot - I3L412
swissprot - K7EL17
swissprot - K7ENA6
swissprot - Q68DZ5
Ensembl - ENSG00000141480
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arrb2aENSDARG00000039215Danio rerio
 arrb2bENSDARG00000011545Danio rerio
 Arrb2ENSMUSG00000060216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARRB1 / P49407 / arrestin beta 1ENSG0000013748673
SAG / P10523 / S-antigen visual arrestinENSG0000013056150
ARR3 / P36575 / arrestin 3ENSG0000012050050


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002031 G-protein coupled receptor internalization TAS
 biological_processGO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway NAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IGI
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IEA
 biological_processGO:0032695 negative regulation of interleukin-12 production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045953 negative regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling NAS
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0060079 excitatory postsynaptic potential NAS
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031691 alpha-1A adrenergic receptor binding IEA
 molecular_functionGO:0031692 alpha-1B adrenergic receptor binding IEA
 molecular_functionGO:0031701 angiotensin receptor binding IPI
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0031762 follicle-stimulating hormone receptor binding IEA
 molecular_functionGO:0031826 type 2A serotonin receptor binding IEA
 molecular_functionGO:0031859 platelet activating factor receptor binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA
 molecular_functionGO:1990763 arrestin family protein binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000128602 SMO / Q99835 / smoothened, frizzled class receptor  / complex / reaction
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / reaction / complex
 ENSG00000135144 DTX1 / Q86Y01 / deltex E3 ubiquitin ligase 1  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction / complex
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / reaction / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000131437 KIF3A / Q9Y496 / kinesin family member 3A  / reaction / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000181072 CHRM2 / P08172 / cholinergic receptor muscarinic 2  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / complex / reaction
 ENSG00000126895 AVPR2 / P30518 / arginine vasopressin receptor 2  / reaction / complex
 ENSG00000077254 USP33 / Q8TEY7 / ubiquitin specific peptidase 33  / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000101200 AVP / P01185 / arginine vasopressin  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr