ENSG00000181072


Homo sapiens

Features
Gene ID: ENSG00000181072
  
Biological name :CHRM2
  
Synonyms : cholinergic receptor muscarinic 2 / CHRM2 / P08172
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q33
Gene start: 136868669
Gene end: 137020255
  
Corresponding Affymetrix probe sets: 221330_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000319984
Ensembl peptide - ENSP00000384401
Ensembl peptide - ENSP00000399745
Ensembl peptide - ENSP00000415386
NCBI entrez gene - 1129     See in Manteia.
OMIM - 118493
RefSeq - NM_001006630
RefSeq - NM_001006631
RefSeq - NM_001006632
RefSeq - XM_011515769
RefSeq - NM_000739
RefSeq - NM_001006626
RefSeq - NM_001006627
RefSeq - NM_001006628
RefSeq - NM_001006629
RefSeq Peptide - NP_000730
RefSeq Peptide - NP_001006627
RefSeq Peptide - NP_001006628
RefSeq Peptide - NP_001006629
RefSeq Peptide - NP_001006630
RefSeq Peptide - NP_001006631
RefSeq Peptide - NP_001006632
RefSeq Peptide - NP_001006633
swissprot - P08172
swissprot - A4D1Q0
Ensembl - ENSG00000181072
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrm2aENSDARG00000098612Danio rerio
 chrm2bENSDARG00000116374Danio rerio
 CHRM2ENSGALG00000012894Gallus gallus
 Chrm2ENSMUSG00000045613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHRM4 / P08173 / cholinergic receptor muscarinic 4ENSG0000018072059
CHRM3 / P20309 / cholinergic receptor muscarinic 3ENSG0000013301945
CHRM5 / P08912 / cholinergic receptor muscarinic 5ENSG0000018498443
CHRM1 / P11229 / cholinergic receptor muscarinic 1ENSG0000016853941
HRH1 / P35367 / histamine receptor H1ENSG0000019663924
HRH3 / Q9Y5N1 / histamine receptor H3ENSG0000010118022
HRH4 / Q9H3N8 / histamine receptor H4ENSG0000013448918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000995  Muscarinic acetylcholine receptor family
 IPR001065  Muscarinic acetylcholine receptor M2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006940 regulation of smooth muscle contraction IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway TAS
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IDA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008016 regulation of heart contraction IBA
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity TAS
 molecular_functionGO:1990763 arrestin family protein binding IPI


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (i) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / complex / reaction






 

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