ENSG00000168539


Homo sapiens

Features
Gene ID: ENSG00000168539
  
Biological name :CHRM1
  
Synonyms : cholinergic receptor muscarinic 1 / CHRM1 / P11229
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.3
Gene start: 62908679
Gene end: 62921807
  
Corresponding Affymetrix probe sets: 231783_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306490
Ensembl peptide - ENSP00000441188
Ensembl peptide - ENSP00000444482
NCBI entrez gene - 1128     See in Manteia.
OMIM - 118510
RefSeq - XM_011544742
RefSeq - NM_000738
RefSeq Peptide - NP_000729
swissprot - P11229
swissprot - Q53XZ3
swissprot - F5GZF8
Ensembl - ENSG00000168539
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrm1aENSDARG00000037292Danio rerio
 Chrm1ENSMUSG00000032773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHRM5 / P08912 / cholinergic receptor muscarinic 5ENSG0000018498456
CHRM3 / P20309 / cholinergic receptor muscarinic 3ENSG0000013301955
CHRM4 / P08173 / cholinergic receptor muscarinic 4ENSG0000018072043
CHRM2 / P08172 / cholinergic receptor muscarinic 2ENSG0000018107242
HRH1 / P35367 / histamine receptor H1ENSG0000019663928
HRH3 / Q9Y5N1 / histamine receptor H3ENSG0000010118026
HRH4 / Q9H3N8 / histamine receptor H4ENSG0000013448920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000995  Muscarinic acetylcholine receptor family
 IPR002228  Muscarinic acetylcholine receptor M1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003056 regulation of vascular smooth muscle contraction IBA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway TAS
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0040012 regulation of locomotion IEA
 biological_processGO:0043270 positive regulation of ion transport IGI
 biological_processGO:0046541 saliva secretion IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity IEA


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr