ENSG00000134489


Homo sapiens

Features
Gene ID: ENSG00000134489
  
Biological name :HRH4
  
Synonyms : histamine receptor H4 / HRH4 / Q9H3N8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q11.2
Gene start: 24460629
Gene end: 24479957
  
Corresponding Affymetrix probe sets: 221169_s_at (Human Genome U133 Plus 2.0 Array)   221170_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000256906
Ensembl peptide - ENSP00000402526
NCBI entrez gene - 59340     See in Manteia.
OMIM - 606792
RefSeq - NM_001160166
RefSeq - NM_001143828
RefSeq - NM_021624
RefSeq Peptide - NP_001137300
RefSeq Peptide - NP_001153638
RefSeq Peptide - NP_067637
swissprot - Q9H3N8
Ensembl - ENSG00000134489
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01084564.1ENSDARG00000045137Danio rerio
 LO017843.1ENSDARG00000103139Danio rerio
 HRH4ENSGALG00000026092Gallus gallus
 Hrh4ENSMUSG00000037346Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HRH3 / Q9Y5N1 / histamine receptor H3ENSG0000010118039
CHRM3 / P20309 / cholinergic receptor muscarinic 3ENSG0000013301927
CHRM5 / P08912 / cholinergic receptor muscarinic 5ENSG0000018498427
CHRM1 / P11229 / cholinergic receptor muscarinic 1ENSG0000016853923
CHRM4 / P08173 / cholinergic receptor muscarinic 4ENSG0000018072022
HRH1 / P35367 / histamine receptor H1ENSG0000019663922
CHRM2 / P08172 / cholinergic receptor muscarinic 2ENSG0000018107222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR008102  Histamine H4 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0043408 regulation of MAPK cascade IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004969 histamine receptor activity NAS


Pathways (from Reactome)
Pathway description
Histamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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